Evidence map›Paper›PMID 26988627›Full record

ReviewExperimental eye research2017

Organization of lipids in fiber-cell plasma membranes of the eye lens.

Witold K Subczynski, Laxman Mainali, Marija Raguz, William J O'Brien

Abstract readReview
In one paragraph

Review in Experimental eye research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Deficiency in glutathione peroxidase 4 (GPX4) results in abnormal lens development and newborn cataract.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
  5. Article
  6. Interaction of βInternational journal of molecular sciences · 2023
    Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Witold K SubczynskiDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Electronic address: subczyn@mcw.edu.
Laxman MainaliDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Marija RaguzDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA; Department of Medical Physics and Biophysics, School of Medicine, University of Split, Split, Croatia.
William J O'BrienDepartment of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Medical College of Wisconsin · USUniversity of Split · HR

Funding

TR&D Project 3P41EB001980 · NIBIB · MEDICAL COLLEGE OF WISCONSIN · PI KLUG, CANDICE S · 2003 to 2017
$16.3M
MORPHOLOGY MODULEP30EY001931 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI LINK, BRIAN A · 1985 to 2016
$9.8M
DEVELOPMENT OF BIOMEDICAL ESR INSTRUMENTATIONR01EB002052 · NIBIB · MEDICAL COLLEGE OF WISCONSIN · PI KLUG, CANDICE S · 2003 to 2015
$6.4M
Liquid Rafts in Eye Lens: Discrimination by Pulse EPRR01EY015526 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI SUBCZYNSKI, WITOLD K · 2005 to 2019
$4.8M
NEI NIH HHS P30 EY001931NEI NIH HHS R01 EY015526NIBIB NIH HHS P41 EB001980NIBIB NIH HHS R01 EB002052
6 · The paper itself

Abstract

The plasma membrane together with the cytoskeleton forms the only supramolecular structure of the matured fiber cell which accounts for mostly all fiber cell lipids. The purpose of this review is to inform researchers about the importance of the lipid bilayer portion of the lens fiber cell plasma membranes in the maintaining lens homeostasis, and thus protecting against cataract development.

Indexed as

AnimalsCell MembraneCholesterolHumansHydrophobic and Hydrophilic InteractionsLens, CrystallineLipid BilayersMembrane FluidityMembrane LipidsOxygenPhospholipidsCholesterolLipid BilayersMembrane LipidsOxygenPhospholipidsCholesterolCholesterol bilayer domainCholesterol crystalsMembrane domainsOxygen permeationSpin labeling

Identifiers

PMID26988627
PMCPMC5023447
OpenAlexW2297639887

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.