SynthesisBMJ open2016
Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258: a systematic review and meta-analysis.
Synthesis in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
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- A novel post-translational modification of fimbriae drives pathogenicity inbioRxiv : the preprint server for biology · 2025Article
- De novo virulence feature discovery and risk assessment in Klebsiella pneumoniae based on microbial genome vectorization.Communications biology · 2025Article
- Detection of O25B-ST131 clone andPeerJ · 2025Article
- Structural and functional analysis of Escherichia coli membrane disruption by Ib-M peptides.PloS one · 2025Article
- Tracing carriage, acquisition, and transmission of ESBL-producing Escherichia coli over two years in a tertiary care hospital.Genome medicine · 2024Observational
- Characterization of Extraintestinal PathogenicVeterinary sciences · 2024Article
- Epidemiology, Virulence and Antimicrobial Resistance ofMicroorganisms · 2024Article
- Multidrug resistance in pathogenicFrontiers in veterinary science · 2024Article
- Population Analysis of Escherichia coli Sequence Type 361 and Reduced Cefiderocol Susceptibility, France.Emerging infectious diseases · 2023Article
- Improvement and Validation of a Multi-Locus Variable Number of Tandem Repeats Analysis (MLVA8+) forMicroorganisms · 2023Article
- Article
- Dynamics of extended-spectrum beta-lactamase-producingMicrobial genomics · 2021Article
- Antibiotic Susceptibility of Escherichia coli Among Infants Admitted to Neonatal Intensive Care Units Across the US From 2009 to 2017.JAMA pediatrics · 2021Observational
- Potential Application ofFrontiers in microbiology · 2021Review
- Systematic Comparison of Epidemic and Non-Epidemic Carbapenem ResistantFrontiers in cellular and infection microbiology · 2021Article
- Antimicrobial resistance at the human-animal interface in the Pastoralist Communities of Kasese District, South Western Uganda.Scientific reports · 2020Article
- Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae.Nature medicine · 2020Article
- Companion Animals Are Spillover Hosts of the Multidrug-Resistant Human ExtraintestinalFrontiers in microbiology · 2020Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesObservational studies have suggested that Escherichia coli sequence type (ST) 131 and Klebsiella pneumoniae ST258 have hyperendemic properties. This would be obvious from continuously high incidence and/or prevalence of carriage or infection with these bacteria in specific patient populations. Hyperendemicity could result from increased transmissibility, longer duration of infectiousness, and/or higher pathogenic potential as compared with other lineages of the same species. The aim of our research is to quantitatively estimate these critical parameters for E. coli ST131 and K. pneumoniae ST258, in order to investigate whether E. coli ST131 and K. pneumoniae ST258 are truly hyperendemic clones. PRIMARY OUTCOME MEASURES: A systematic literature search was performed to assess the evidence of transmissibility, duration of infectiousness, and pathogenicity for E. coli ST131 and K. pneumoniae ST258. Meta-regression was performed to quantify these characteristics.
resultsThe systematic literature search yielded 639 articles, of which 19 data sources provided information on transmissibility (E. coli ST131 n=9; K. pneumoniae ST258 n=10)), 2 on duration of infectiousness (E. coli ST131 n=2), and 324 on pathogenicity (E. coli ST131 n=285; K. pneumoniae ST258 n=39). Available data on duration of carriage and on transmissibility were insufficient for quantitative assessment. In multivariable meta-regression E. coli isolates causing infection were associated with ST131, compared to isolates only causing colonisation, suggesting that E. coli ST131 can be considered more pathogenic than non-ST131 isolates. Date of isolation, location and resistance mechanism also influenced the prevalence of ST131. E. coli ST131 was 3.2 (95% CI 2.0 to 5.0) times more pathogenic than non-ST131. For K. pneumoniae ST258 there were not enough data for meta-regression assessing the influence of colonisation versus infection on ST258 prevalence.
conclusionsWith the currently available data, it cannot be confirmed nor rejected, that E. coli ST131 or K. pneumoniae ST258 are hyperendemic clones.
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