Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2016
Risk Factors for Hip Fracture in Older Men: The Osteoporotic Fractures in Men Study (MrOS).
Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 9 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- What is the association between physical activity and fracture risk in middle-aged adults (aged 30-60): a systematic review and synthesis without meta-analysis (SWIM).Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Pooled it
- Association between a history of major osteoporotic fractures and subsequent hip fracture: a systematic review and meta-analysis.Archives of osteoporosis · 2024Pooled it
- Alcohol Consumption and Risk of Fractures: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- The global prevalence of myocardial infarction: a systematic review and meta-analysis.BMC cardiovascular disorders · 2023Pooled it
- The relationship of hip fracture and thyroid disorders: a systematic review.Frontiers in endocrinology · 2023Pooled it
- Smoking and fracture risk in men: a meta-analysis of cohort studies, using both frequentist and Bayesian approaches.Scientific reports · 2022Pooled it
- Physical exercise for bone health in men with prostate cancer receiving androgen deprivation therapy: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Pooled it
- Dietary protein and bone health across the life-course: an updated systematic review and meta-analysis over 40 years.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Pooled it
- Effect of Cigarette Smoking on Risk of Hip Fracture in Men: A Meta-Analysis of 14 Prospective Cohort Studies.PloS one · 2016Pooled it
- Association between self-rated health and the risk of hip fracture and mortality in a cohort of older women during a 10-year follow-up.PloS one · 2021Trial
- Letter to the Editor from Dandinoğlu: "Aggressive macroprolactinoma refractory to multiple lines of localized and systemic therapy".JCEM case reports · 2026Article
- The Osteoporotic Fractures in Men study (MrOS): a 25-yr landmark study of skeletal health in older men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- High-resolution peripheral quantitative CT of the proximal fifth metatarsal reveals microstructural similarity between Lawrence and Botte zones I and II.Bone & joint research · 2026Article
- Male osteoporosis: pathophysiology, risk assessment, and evidence-based management.Turkish journal of medical sciences · 2026Review
- Inequities Across the Spectrum of Osteoporosis Care and Post-Fracture Management in Men.Current osteoporosis reports · 2025Review
- The Effect of Protein Intake on Bone Disease, Kidney Disease, and Sarcopenia: A Systematic Review.Current developments in nutrition · 2025Review
- Article
- Effect of timing of surgery on postoperative complications and prognosis in elderly patients with hip fractures.Frontiers in medicine · 2025Article
- Osteoporosis in Older Men: Informing Patient Management and Improving Health-Related Outcomes.Drugs & aging · 2025Review
- Involvement of cognitive abilities in the occurrence of fractures in fallers aged 55 years or older: a cross-sectional study.Aging clinical and experimental research · 2024Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 10 institutions in 1 country.
Funding
Abstract
Almost 30% of hip fractures occur in men; the mortality, morbidity, and loss of independence after hip fractures are greater in men than in women. To comprehensively evaluate risk factors for hip fracture in older men, we performed a prospective study of 5994 men, primarily white, age 65+ years recruited at six US clinical centers. During a mean of 8.6 years of 97% complete follow-up, 178 men experienced incident hip fractures. Information on risk factors including femoral neck bone mineral density (FNBMD) was obtained at the baseline visit. Cox proportional hazards models were used to calculate the hazard ratio (HR) with 95% confidence intervals; Fine and Gray models adjusted for competing mortality risk. Older age (≥75 years), low FNBMD, currently smoking, greater height and height loss since age 25 years, history of fracture, use of tricyclic antidepressants, history of myocardial infarction or angina, hyperthyroidism or Parkinson's disease, lower protein intake, and lower executive function were all associated with an increased hip fracture risk. Further adjustment for competing mortality attenuated HR for smoking, hyperthyroidism, and Parkinson's disease. The incidence rate of hip fracture per 1000 person-years (PY) was greatest in men with FNBMD T-scores <-2.5 (white women reference database) who also had 4+ risk factors, 33.4. Men age ≥80 years with 3+ major comorbidities experienced hip fracture at rates of 14.52 versus 0.88 per 1000 PY in men age <70 years with zero comorbidities. Older men with low FNBMD, multiple risk factors, and multimorbidity have a high risk of hip fracture. Many of these assessments can easily be incorporated into routine clinical practice and may lead to improved risk stratification. © 2016 American Society for Bone and Mineral Research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.