ArticleThe neuroradiology journal2016
Usefulness of quantitative peritumoural perfusion and proton spectroscopic magnetic resonance imaging evaluation in differentiating brain gliomas from solitary brain metastases.
Article in The neuroradiology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Perfusion MRI as a diagnostic biomarker for differentiating glioma from brain metastasis: a systematic review and meta-analysis.European radiology · 2018Pooled it
- Differentiation between high-grade gliomas and solitary brain metastases based on multidiffusion MRI model quantitative analysis.Frontiers in oncology · 2024Article
- Accuracy of apparent diffusion coefficient in differentiation of glioblastoma from metastasis.The neuroradiology journal · 2021Article
- Quantitative MRI using relaxometry in malignant gliomas detects contrast enhancement in peritumoral oedema.Scientific reports · 2020Article
- Brain Tumor Characterization Using Multibiometric Evaluation of MRI.Tomography (Ann Arbor, Mich.) · 2018Article
- Mechanisms and Therapy for Cancer Metastasis to the Brain.Frontiers in oncology · 2018Review
- Brain metastases: neuroimaging.Handbook of clinical neurology · 2018Review
- T1-weighted dynamic contrast-enhanced brain magnetic resonance imaging: A preliminary study with low infusion rate in pediatric patients.The neuroradiology journal · 2017Article
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5 authors.
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Abstract
objectivesThe purpose of our study was to evaluate whether peritumoural perfusion weighted and proton spectroscopic magnetic resonance imaging can be used in differentiating between primary gliomas and solitary metastases.
methodsTen low-grade gliomas, eight high-grade gliomas and 10 metastases were prospectively evaluated with magnetic resonance imaging, dynamic susceptibility contrast enhanced perfusion imaging and single-voxel proton magnetic resonance spectroscopy before surgical resection or stereotactic biopsy. Maximal relative cerebral blood volume values were calculated drawing three regions of interest of 2 cm(2) in the non-enhancing peritumoural areas. Maximal relative cerebral blood volume values were normalised to that of contralateral normal-appearing white matter. Maximal choline/creatine ratios were calculated from three voxels of 10 cm(3) placed in the peritumoural areas defined as non-enhancing peritumoural white matter surrounding the tumour. The tumour grade presumed with these values was compared to histopathological grading. Differences in the study parameters between groups were assessed using the Mann-Whitney test. A receiver operating characteristic analysis was performed to determine cut-off values.
resultsA clear relative cerebral blood volume cut-off value of 1.88 was detected for differentiating low-grade gliomas from high-grade gliomas. A clear relative cerebral blood volume cut-off value of 1.20 was detected for differentiation of metastases from gliomas. The differences in the choline/creatine ratios in the peritumoural regions of high-grade gliomas and of solitary metastasis were statistically significant (P < 0.001) but a clear cut-off value was not found.
conclusionOur preliminary data support the hypothesis that peritumoural perfusion-weighted imaging can assist in preoperative differentiation between a glioma and a solitary metastasis.
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