ArticleMetallomics : integrated biometal science2016
A multimodal imaging workflow to visualize metal mixtures in the human placenta and explore colocalization with biological response markers.
Article in Metallomics : integrated biometal science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Impact of intermittent lead exposure on hominid brain evolution.Science advances · 2025Article
- Integration of elemental imaging and spatial transcriptomic profiling for proof-of-concept metals-based pathway analysis of colon tumor microenvironment.Metallomics : integrated biometal science · 2025Article
- Quantitative distribution of essential elements and non-essential metals in breast cancer tissues by LA-ICP-TOF-MS.Analytical and bioanalytical chemistry · 2025Article
- Integrative co-registration of elemental imaging and histopathology for enhanced spatial multimodal analysis of tissue sections through TRACE.Bioinformatics advances · 2025Article
- Equine odontoclastic tooth resorption and hypercementosis (EOTRH): microspatial distribution of trace elements in hypercementosis-affected and unaffected hard dental tissues.Scientific reports · 2023Article
- Brief Communication: Elemental Models of Primate Nursing and Weaning Revisited.American journal of biological anthropology · 2023Article
- Microspatial distribution of trace elements in feline dental hard tissues: early life exposure to essential and toxic elements.Frontiers in veterinary science · 2023Article
- Praegnatio Perturbatio-Impact of Endocrine-Disrupting Chemicals.Endocrine reviews · 2021Review
- Exposure to toxic metals and per- and polyfluoroalkyl substances and the risk of preeclampsia and preterm birth in the United States: a review.American journal of obstetrics & gynecology MFM · 2021Review
- Methodology for the Implementation of Internal Standard to Laser-Induced Breakdown Spectroscopy Analysis of Soft Tissues.Sensors (Basel, Switzerland) · 2021Article
- Mass Spectrometry Imaging: A Review of Emerging Advancements and Future Insights.Analytical chemistry · 2018Review
- Cyclical nursing patterns in wild orangutans.Science advances · 2017Article
- Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS).Journal of visualized experiments : JoVE · 2017Article
- Zebrafish in Toxicology and Environmental Health.Current topics in developmental biology · 2017Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
Fetal exposure to essential and toxic metals can influence life-long health trajectories. The placenta regulates chemical transmission from maternal circulation to the fetus and itself exhibits a complex response to environmental stressors. The placenta can thus be a useful matrix to monitor metal exposures and stress responses in utero, but strategies to explore the biologic effects of metal mixtures in this organ are not well-developed. In this proof-of-concept study, we used laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) to measure the distributions of multiple metals in placental tissue from a low-birth-weight pregnancy, and we developed an approach to identify the components of metal mixtures that colocalized with biological response markers. Our novel workflow, which includes custom-developed software tools and algorithms for spatial outlier identification and background subtraction in multidimensional elemental image stacks, enables rapid image processing and seamless integration of data from elemental imaging and immunohistochemistry. Using quantitative spatial statistics, we identified distinct patterns of metal accumulation at sites of inflammation. Broadly, our multiplexed approach can be used to explore the mechanisms mediating complex metal exposures and biologic responses within placentae and other tissue types. Our LA-ICP-MS image processing workflow can be accessed through our interactive R Shiny application 'shinyImaging', which is available at or through our laboratory's website, .
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