ArticleMicrobiologyOpen2016
Anaerobic microbial community response to methanogenic inhibitors 2-bromoethanesulfonate and propynoic acid.
Article in MicrobiologyOpen, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 55 citations in OpenAlex.
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- Effects of coenzyme M and methyl-coenzyme M on the efficacy of inhibitors of methanogenesis in rumen cultures.Scientific reports · 2026Article
- A Small-Molecule Inhibitor of Gut Bacterial Urease Protects the Host from Liver Injury.ACS chemical biology · 2025Article
- Superior ability of dietary fiber utilization in obese breed pigs linked to gut microbial hydrogenotrophy.ISME communications · 2025Article
- Coastal methane emissions driven by aerotolerant methanogens using seaweed and seagrass metabolites.Nature geoscience · 2025Article
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- Targeting the human gut microbiome with small-molecule inhibitors.Nature reviews. Chemistry · 2023Review
- Competitive Reactions during Ethanol Chain Elongation Were Temporarily Suppressed by Increasing Hydrogen Partial Pressure through Methanogenesis Inhibition.Environmental science & technology · 2023Article
- Biological methane production and accumulation under sulfate-rich conditions at Cape Lookout Bight, NC.Frontiers in microbiology · 2023Article
- Synthetic oligonucleotides as quantitative PCR standards for quantifying microbial genes.Frontiers in microbiology · 2023Article
- Article
- Inhibition of enteric methanogenesis in dairy cows induces changes in plasma metabolome highlighting metabolic shifts and potential markers of emission.Scientific reports · 2020Article
- Bioengineering of anaerobic digestion for volatile fatty acids, hydrogen or methane production: A critical review.Bioengineered · 2019Review
- Article
- Anaerobic microbial community response to methanogenic inhibitors 2-bromoethanesulfonate and propynoic acid.MicrobiologyOpen · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methanogenic inhibitors are often used to study methanogenesis in complex microbial communities or inhibit methanogens in the gastrointestinal tract of livestock. However, the resulting structural and functional changes in archaeal and bacterial communities are poorly understood. We characterized microbial community structure and activity in mesocosms seeded with cow dung and municipal wastewater treatment plant anaerobic digester sludge after exposure to two methanogenic inhibitors, 2-bromoethanesulfonate (BES) and propynoic acid (PA). Methane production was reduced by 89% (0.5 mmol/L BES), 100% (10 mmol/LBES), 24% (0.1 mmol/LPA), and 95% (10 mmol/LPA). Using modified primers targeting the methyl-coenzyme M reductase (mcrA) gene, changes in mcrA gene expression were found to correspond with changes in methane production and the relative activity of methanogens. Methanogenic activity was determined by the relative abundance of methanogen 16S rRNA cDNA as a percentage of the total community 16S rRNA cDNA. Overall, methanogenic activity was lower when mesocosms were exposed to higher concentrations of both inhibitors, and aceticlastic methanogens were inhibited to a greater extent than hydrogenotrophic methanogens. Syntrophic bacterial activity, measured by 16S rRNA cDNA, was also reduced following exposure to both inhibitors, but the overall structure of the active bacterial community was not significantly affected.
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