ArticleScientific reports2016
Contrast-enhanced optical coherence tomography with picomolar sensitivity for functional in vivo imaging.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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Who cites it
42 citing papers in PubMed.
- Computational and experimental investigation of nanoparticle effects on tissue optical properties and optical coherence tomography imaging.Biomedical optics express · 2026Article
- Roadmap for light interaction with biophotonic surfaces and their diverse applications.Journal of biomedical optics · 2026Article
- Optical coherence tomography with enhanced contrast using oriented magnetic nanorods.Frontiers of optoelectronics · 2025Article
- Magnetically Controlled Reversible Photomagnetic Nanoactuators for Dynamic Contrast Enhancement in Optical Coherence Tomography.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- OCT in Oncology and Precision Medicine: From Nanoparticles to Advanced Technologies and AI.Bioengineering (Basel, Switzerland) · 2025Review
- Multimodal optoacoustic imaging: methods and contrast materials.Chemical Society reviews · 2024Review
- Gold nanoparticle-mediated photothermal therapy guidance with multi-wavelength photomagnetic imaging.Photodiagnosis and photodynamic therapy · 2024Article
- Gold Polymer Nanomaterials: A Promising Approach for Enhanced Biomolecular Imaging.Nanotheranostics · 2024Review
- Multimodal imaging of laser-induced choroidal neovascularization in pigmented rabbits.Scientific reports · 2023Article
- Nanoparticle-Based Techniques for Bladder Cancer Imaging: A Review.International journal of molecular sciences · 2023Review
- Spectral characteristics of gold nanoparticle doped optical fibre under axial strain.Scientific reports · 2022Article
- Mesoporous Silica-Coated Gold Nanoparticles for Multimodal Imaging and Reactive Oxygen Species Sensing of Stem Cells.ACS applied nano materials · 2022Article
- Molecular Contrast Optical Coherence Tomography and Its Applications in Medicine.International journal of molecular sciences · 2022Review
- Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography.Nano letters · 2021Article
- In vivo optical molecular imaging of inflammation and immunity.Journal of molecular medicine (Berlin, Germany) · 2021Review
- Gold Nanorod Enhanced Photoacoustic Microscopy and Optical Coherence Tomography of Choroidal Neovascularization.ACS applied materials & interfaces · 2021Article
- Gold nanomaterials for optical biosensing and bioimaging.Nanoscale advances · 2021Review
- High-resolution, depth-resolved vascular leakage measurements using contrast-enhanced, correlation-gated optical coherence tomography in mice.Biomedical optics express · 2021Article
- X-ray-Based Techniques to Study the Nano-Bio Interface.ACS nano · 2021Article
- Gold nanoparticles to enhance ophthalmic imaging.Biomaterials science · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Optical Coherence Tomography (OCT) enables real-time imaging of living tissues at cell-scale resolution over millimeters in three dimensions. Despite these advantages, functional biological studies with OCT have been limited by a lack of exogenous contrast agents that can be distinguished from tissue. Here we report an approach to functional OCT imaging that implements custom algorithms to spectrally identify unique contrast agents: large gold nanorods (LGNRs). LGNRs exhibit 110-fold greater spectral signal per particle than conventional GNRs, which enables detection of individual LGNRs in water and concentrations as low as 250 pM in the circulation of living mice. This translates to ~40 particles per imaging voxel in vivo. Unlike previous implementations of OCT spectral detection, the methods described herein adaptively compensate for depth and processing artifacts on a per sample basis. Collectively, these methods enable high-quality noninvasive contrast-enhanced imaging of OCT in living subjects, including detection of tumor microvasculature at twice the depth achievable with conventional OCT. Additionally, multiplexed detection of spectrally-distinct LGNRs was demonstrated to observe discrete patterns of lymphatic drainage and identify individual lymphangions and lymphatic valve functional states. These capabilities provide a powerful platform for molecular imaging and characterization of tissue noninvasively at cellular resolution, called MOZART.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.