ArticleScientific reports2016
Spines slow down dendritic chloride diffusion and affect short-term ionic plasticity of GABAergic inhibition.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Dendritic heterosynaptic plasticity arises from calcium-based input learning.Communications biology · 2026Article
- Spatiotemporal Dynamics of Lateral NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Spatio-temporal dynamics of lateral NabioRxiv : the preprint server for biology · 2025Article
- Vesicle and reaction-diffusion hybrid modeling with STEPS.Communications biology · 2024Article
- STEPS 4.0: Fast and memory-efficient molecular simulations of neurons at the nanoscale.Frontiers in neuroinformatics · 2022Article
- Coincident glutamatergic depolarizations enhance GABAA receptor-dependent Cl- influx in mature and suppress Cl- efflux in immature neurons.PLoS computational biology · 2021Article
- When Are Depolarizing GABAergic Responses Excitatory?Frontiers in molecular neuroscience · 2021Review
- NKCC-1 mediated ClScientific reports · 2020Article
- Chloride dynamics alter the input-output properties of neurons.PLoS computational biology · 2020Article
- Geometric principles of second messenger dynamics in dendritic spines.Scientific reports · 2019Article
- Interactions between Membrane Resistance, GABA-A Receptor Properties, Bicarbonate Dynamics and ClInternational journal of molecular sciences · 2019Article
- Coincident Activation of Glutamate Receptors Enhances GABAFrontiers in cellular neuroscience · 2019Article
- Aging is associated with a mild acidification in neocortical human neurons in vitro.Journal of neural transmission (Vienna, Austria : 1996) · 2018Article
- Article
- Giant Depolarizing Potentials Trigger Transient Changes in the Intracellular ClFrontiers in cellular neuroscience · 2018Article
- Impaired Motor Coordination and Learning in Mice Lacking Anoctamin 2 Calcium-Gated Chloride Channels.Cerebellum (London, England) · 2017Article
- Emerging Mechanisms Underlying Dynamics of GABAergic Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Dendritic diameter influences the rate and magnitude of hippocampal cAMP and PKA transients during β-adrenergic receptor activation.Neurobiology of learning and memory · 2017Article
- Diminished KCC2 confounds synapse specificity of LTP during senescence.Nature neuroscience · 2016Review
- Dendritic Spines as Tunable Regulators of Synaptic Signals.Frontiers in psychiatry · 2016Article
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8 authors.
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Abstract
Cl(-) plays a crucial role in neuronal function and synaptic inhibition. However, the impact of neuronal morphology on the diffusion and redistribution of intracellular Cl(-) is not well understood. The role of spines in Cl(-) diffusion along dendritic trees has not been addressed so far. Because measuring fast and spatially restricted Cl(-) changes within dendrites is not yet technically possible, we used computational approaches to predict the effects of spines on Cl(-) dynamics in morphologically complex dendrites. In all morphologies tested, including dendrites imaged by super-resolution STED microscopy in live brain tissue, spines slowed down longitudinal Cl(-) diffusion along dendrites. This effect was robust and could be observed in both deterministic as well as stochastic simulations. Cl(-) extrusion altered Cl(-) diffusion to a much lesser extent than the presence of spines. The spine-dependent slowing of Cl(-) diffusion affected the amount and spatial spread of changes in the GABA reversal potential thereby altering homosynaptic as well as heterosynaptic short-term ionic plasticity at GABAergic synapses in dendrites. Altogether, our results suggest a fundamental role of dendritic spines in shaping Cl(-) diffusion, which could be of relevance in the context of pathological conditions where spine densities and neural excitability are perturbed.
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