ArticleInternational journal of legal medicine2016
Fatal toxicity index of medicinal drugs based on a comprehensive toxicology database.
Article in International journal of legal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Short-term sleep benefitsFrontiers in pharmacology · 2026Pooled it
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- Antidepressant metabolite concentrations and metabolite-to-parent drug ratios in postmortem femoral blood.Journal of analytical toxicology · 2026Article
- The relative toxicity of medicines detected after poisoning suicide deaths in Australia, 2013-19: a data linkage case series study.The Medical journal of Australia · 2025Article
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- Fatal Intoxications with Zopiclone-A Cause for Concern?Drug safety · 2024Article
- The cardiovascular safety of tricyclic antidepressants in overdose and in clinical use.Therapeutic advances in psychopharmacology · 2024Review
- Fatal concentrations of antidepressant and antipsychotic drugs in postmortem femoral blood.Journal of analytical toxicology · 2023Article
- A comparative study of postmortem distribution and postmortem diffusion of tramadol in rabbits.Scientific reports · 2023Article
- Post-mortem oxycodone blood concentrations of hospitalized cancer and surgery patients compared with fatal poisonings.International journal of legal medicine · 2022Article
- Alprazolam-related deaths in Scotland, 2004-2020.Journal of psychopharmacology (Oxford, England) · 2022Article
- Alprazolam and lorazepam overdose and the absence of brainstem reflexes.BMJ case reports · 2022Article
- Drug-related Death low Registration in Iran: A Mixed Method Approach for Causes, Recommendations to Solve This Problem and Geographical Evaluation of an Intervention.Addiction & health · 2022Article
- A 13-Year National Monitoring Study to Assess Narcotic Prescriptions and Indications (2007-2019).Drug safety · 2022Article
- Early Detection of Prescription Drug Abuse Using Doctor Shopping Monitoring From Claims Databases: Illustration From the Experience of the French Addictovigilance Network.Frontiers in psychiatry · 2021Review
- Current Evidence on Abuse and Misuse of Gabapentinoids.Drug safety · 2020Review
- Article
- Drug trends and harm related to new psychoactive substances (NPS) in Sweden from 2010 to 2016: Experiences from the STRIDA project.PloS one · 2020Article
- Amitriptyline accumulation in tissues after coated activated charcoal hemoperfusion-a randomized controlled animal poisoning model.Naunyn-Schmiedeberg's archives of pharmacology · 2019Article
- The relative lethal toxicity of pharmaceutical and illicit substances: A 16-year study of the Greater Newcastle Hunter Area, Australia.British journal of clinical pharmacology · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fatal toxicity index (FTI) is the absolute number of fatal poisonings caused by a particular drug divided by its consumption figure. Consequently, it is a useful measure in evaluating toxicity of the drug and its relevance in fatal poisonings. In this study, we assessed the FTI of medicinal drugs in 3 years (2005, 2009, and 2013) in Finland. As the measure of drug consumption, we used the number of defined daily doses (DDD) per population in each year. There were 70 medicinal drugs in Finland for which the mean FTI expressed as the number of deaths per million DDD over the three study years was higher or equal to 0.1. The Anatomical Therapeutic Chemical (ATC) classification system was used for the classification of the active ingredients of medicinal drugs according to the organ or system which they act on. Of these 70 drugs, 55 drugs (78.6 %) acted on the nervous system (denoted by ATC code N), 11 (15.7 %) on the cardiovascular system (C), three (4.3 %) on the alimentary tract and metabolism (A), and one (1.4 %) on the musculoskeletal system (M). The nervous system drugs consisted of 20 psycholeptics, (ATC code N05), 20 psychoanaleptics (N06), eight analgesics (N02), six antiepileptics (N03), and one other nervous system drug (N07). The highest individual FTIs were associated with the opioids methadone, dextropropoxyphene, oxycodone, tramadol, and morphine; the antipsychotics levomepromazine and chlorprothixene; and the antidepressants doxepin, amitriptyline, trimipramine, and bupropion. Buprenorphine was not included in the study, because most of the fatal buprenorphine poisonings were due to smuggled tablets. A clearly increasing trend in FTI was observed with pregabalin and possibly with bupropion, both drugs emerging as abused substances.
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