ArticleeLife2016
Birth order dependent growth cone segregation determines synaptic layer identity in the Drosophila visual system.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Formation of sensory maps: New tools reveal novel insights into neural development.Current opinion in neurobiology · 2025Review
- Synaptic promiscuity in brain development.Current biology : CB · 2024Review
- Neural specification, targeting, and circuit formation during visual system assembly.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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- The Cytoplasmic LIM Domain Protein Espinas Contributes to Photoreceptor Layer Selection in the Visual System.Biology · 2020Article
- Neuronal strategies for meeting the right partner during brain wiring.Current opinion in neurobiology · 2020Review
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- Retinoic Acid Organizes the Zebrafish Vagus Motor Topographic Map via Spatiotemporal Coordination of Hgf/Met Signaling.Developmental cell · 2020Article
- Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring.Nature communications · 2020Article
- Cellular and synaptic adaptations of neural circuits processing skylight polarization in the fly.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- Gene regulatory networks during the development of the Drosophila visual system.Current topics in developmental biology · 2020Review
- Article
- How prolonged expression of Hunchback, a temporal transcription factor, re-wires locomotor circuits.eLife · 2019Article
- N-Cadherin Orchestrates Self-Organization of Neurons within a Columnar Unit in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The Hunchback temporal transcription factor determines motor neuron axon and dendrite targeting inDevelopment (Cambridge, England) · 2019Article
- Article
- Axon Guidance and Collective Cell Migration by Substrate-Derived Attractants.Frontiers in molecular neuroscience · 2019Article
- Temporal and spatial order of photoreceptor and glia projections into optic lobe in Drosophila.Scientific reports · 2018Article
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Authors and funding
4 authors.
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Abstract
The precise recognition of appropriate synaptic partner neurons is a critical step during neural circuit assembly. However, little is known about the developmental context in which recognition specificity is important to establish synaptic contacts. We show that in the Drosophila visual system, sequential segregation of photoreceptor afferents, reflecting their birth order, lead to differential positioning of their growth cones in the early target region. By combining loss- and gain-of-function analyses we demonstrate that relative differences in the expression of the transcription factor Sequoia regulate R cell growth cone segregation. This initial growth cone positioning is consolidated via cell-adhesion molecule Capricious in R8 axons. Further, we show that the initial growth cone positioning determines synaptic layer selection through proximity-based axon-target interactions. Taken together, we demonstrate that birth order dependent pre-patterning of afferent growth cones is an essential pre-requisite for the identification of synaptic partner neurons during visual map formation in Drosophila.
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