ArticleThe Pediatric infectious disease journal2016
Predicting Outcome of Childhood Bacterial Meningitis With a Single Measurement of C-Reactive Protein.
Article in The Pediatric infectious disease journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Clinical and laboratory profiles of acute central nervous system infections in a Chinese pediatric cohort: a five-year retrospective analysis.BMC pediatrics · 2026Article
- Identifying the need for surgical intervention in pediatric bacterial meningitis: single-center experience.Frontiers in pediatrics · 2025Article
- High-risk factors associated with refractory childhood bacterial meningitis in Southwest China.BMC pediatrics · 2023Article
- Changes in the incidence of acute bacterial meningitis caused byFrontiers in pediatrics · 2022Article
- Outcome of childhood bacterial meningitis on three continents.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionC-reactive protein (CRP), a marker of inflammation, shows high serum levels in invasive bacterial infections. We investigated the potential of a single CRP measurement at different phases of acute childhood bacterial meningitis to predict outcomes.
methodsUsing whole-blood finger-prick samples with no centrifugation, CRP was measured quantitatively on arrival and on day 3 or 4 in children participating in 2 prospective, randomized, double-blind treatment studies conducted in Latin America or Angola. The results were compared with patient outcomes.
resultsAlthough initial CRP values from 669 children gave useful prognostic information, the 3rd or 4th day measurements taken from 275 children associated significantly with seizures, slow recovery and low scores on the Glasgow Outcome Scale, with odds ratios for CRP values above the median (62 mg/L) ranging from 2 to 6, 2 to 5, and 3 to 5 (Latin America-Angola), respectively. Hearing impairment, although not full deafness, was 3 to 7 times more likely if CRP was above the median soon after hospitalization.
conclusionsEspecially in resource-poor settings, clinicians have few simple-enough tools to identify the child with meningitis who requires maximum attention. CRP is a worthy addition.
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Registered trials
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