Evidence map›Paper›PMID 26986692›Full record

ArticleCancer investigation2016

Does the Presence of Endometriosis Affect Prognosis of Ovarian Cancer?

Helen E Dinkelspiel, Cathleen Matrai, Sara Pauk, Alain Pierre-Louis, Ya-Lin Chiu, Divya Gupta, Thomas Caputo, Lora Hedrick Ellenson, Kevin Holcomb

Abstract read
In one paragraph

Article in Cancer investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Endometriosis and risk of ovarian cancer: what do we know?Archives of gynecology and obstetrics · 2020
    Review
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Helen E Dinkelspiela Division of Gynecologic Oncology, Weill Cornell Medical College , New York , NY , USA.
Cathleen Matraib Department of Pathology and Laboratory Medicine , Weill Cornell Medical College , New York , NY , USA.
Sara Paukc Weill Cornell Medical College , New York , NY , USA.
Alain Pierre-Louisc Weill Cornell Medical College , New York , NY , USA.
Ya-Lin Chiuc Weill Cornell Medical College , New York , NY , USA.
Divya Guptad Division of Gynecologic Oncology , New York , NY , USA.
Thomas Caputod Division of Gynecologic Oncology , New York , NY , USA.
Lora Hedrick Ellensonb Department of Pathology and Laboratory Medicine , Weill Cornell Medical College , New York , NY , USA.
Kevin Holcombd Division of Gynecologic Oncology , New York , NY , USA.

Funding

Clinical and Translational Science CenterUL1TR000457 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$46.0M
NCATS NIH HHS UL1 TR000457NCATS NIH HHS UL1-TR000457-06
6 · The paper itself

Abstract

Ovarian cancers diagnosed between 2000 and 2013 were examined and cases with and without endometriosis compared. Among 139 epithelial ovarian, there were 49 (35%) with endometriosis and 90 (65%) without endometriosis. Endometriosis associated ovarian cancers were more likely to be confined to the pelvis (54% vs. 9%, p < 0.0001) and lower grade (51% vs. 29%, p = 0.014). Younger age and earlier stage independently predicted the presence of endometriosis (p = 0.0011 and p < 0.0001, respectively). Ovarian cancer patients with endometriosis had improved PFS and OS [(HR = 0.20; 95% CI, 0.09-0.43), (HR = 0.18; 95% CI, 0.04-0.81)], compared to patients without endometriosis; however, endometriosis had no independent prognostic significance.

Indexed as

AgedCarcinoma, Ovarian EpithelialDisease-Free SurvivalEndometriosisFemaleHumansKaplan-Meier EstimateMiddle AgedNeoplasms, Glandular and EpithelialOvarian NeoplasmsPrognosisProportional Hazards ModelsEpidemiologyOutcomes researchOutreachOvarian cancer

Identifiers

PMID26986692
PMCPMC5292825

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.