Evidence map›Paper›PMID 26986511›Full record

ArticleCell death & disease2016

From fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin polymerization inhibitor.

Y Mu, Y Liu, J Xiang, Q Zhang, S Zhai, D P Russo, H Zhu, X Bai, B Yan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Y MuSchool of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, China.
Y LiuSchool of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, China.
J XiangThe Center for Combinatorial Chemistry and Drug Discovery of Jilin University, The School of Pharmaceutical Sciences and The College of Chemistry, Jilin University, Changchun, Jilin, China.
Q ZhangSchool of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, China.
S ZhaiSchool of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, China.
D P RussoThe Rutgers Center for Computational and Integrative Biology, Camden, NJ, USA.
H ZhuThe Rutgers Center for Computational and Integrative Biology, Camden, NJ, USA.
X BaiThe Center for Combinatorial Chemistry and Drug Discovery of Jilin University, The School of Pharmaceutical Sciences and The College of Chemistry, Jilin University, Changchun, Jilin, China.
B YanSchool of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, China.
Shandong University · CNJilin University · CNRutgers, The State University of New Jersey · US

Funding

Predictive Computational Acute Toxicity Modeling by Profiling Chemicals With PublR15ES023148 · NIEHS · RUTGERS THE STATE UNIV OF NJ CAMDEN · PI ZHU, HAO · 2013 to 2018
$941k
NIEHS NIH HHS R15 ES023148
6 · The paper itself

Abstract

A novel tricyclic thiazepine derivative, 6-(p-tolyl)benzo[f] pyrido[2,3-b][1,4] thiazepine 11,11-dioxide (TBPT), exhibits potent inhibitory effects in two non-small-cell lung cancer cell lines, H460 and its drug-resistant variant, H460(TaxR), while exhibiting much less toxic effects on normal human fibroblasts. After five injections of TBPT at a dose of 60 mg/kg, it inhibits H460(TaxR) tumor growth in xenografted mouse models by 66.7% without causing observable toxicity to normal tissues. Based on gene perturbation data and a series of investigations, we reveal that TBPT is not a P-glycoprotein substrate and it inhibits microtubule formation by targeting tubulin, thereby causing cell cycle arrest at the G2/M stage and eventually inducing apoptosis. This redeployment of anti-depressant compound scaffold for anticancer applications provides a promising future for conquering drug-resistant tumors with fewer side effects.

Indexed as

AnimalsCarcinoma, Non-Small-Cell LungCell Line, TumorFemaleHumansLung NeoplasmsMiceMice, NudeThiazepinesXenograft Model Antitumor AssaysThiazepines

Identifiers

PMID26986511
PMCPMC4823954
OpenAlexW2297122627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.