SynthesisMedicine2016
Diagnostic Accuracy of Procalcitonin in Bacterial Meningitis Versus Nonbacterial Meningitis: A Systematic Review and Meta-Analysis.
Synthesis in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 71 citations in OpenAlex.
- Diagnostic Utility of Procalcitonin and Lactate Determination in Cerebrospinal Fluid for the Diagnosis of Neonatal Meningitis.Journal of clinical medicine · 2025Article
- The Diagnostic Utility of Cerebrospinal Fluid Procalcitonin for Acute Bacterial Meningitis and Ventriculitis in Children: A Multicenter Prospective Study.Acta medica Philippina · 2025Article
- Clinical value of heparin-binding protein in adult bacterial intracranial infection.Frontiers in cellular and infection microbiology · 2024Article
- Factors influencing procalcitonin in the cerebrospinal fluid of patients after neurosurgery and its diagnostic value for intracranial infection.BMC neurology · 2023Article
- Procalcitonin for antimicrobial stewardship among cancer patients admitted with COVID-19.eLife · 2022Article
- Comparison of Suspected and Confirmed Internal External Ventricular Drain-Related Infections: A Prospective Multicenter United Kingdom Observational Study.Open forum infectious diseases · 2022Article
- Heparin-Binding Protein (HBP), Neutrophil Gelatinase-Associated Lipocalin (NGAL) and S100 Calcium-Binding Protein B (S100B) Can Confirm Bacterial Meningitis and Inform Adequate Antibiotic Treatment.Antibiotics (Basel, Switzerland) · 2022Article
- Procalcitonin measurement in West Nile virus neuroinvasive disease: A first case series.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2021Article
- SOP: emergency workup in patients with suspected acute bacterial meningitis.Neurological research and practice · 2021Article
- Derivation of a metabolic signature associated with bacterial meningitis in infants.Pediatric research · 2020Article
- A 2020 review on the role of procalcitonin in different clinical settings: an update conducted with the tools of the Evidence Based Laboratory Medicine.Annals of translational medicine · 2020Review
- Procalcitonin in respiratory disease: use as a biomarker for diagnosis and guiding antibiotic therapy.Breathe (Sheffield, England) · 2019Review
- Comparison of the novel ARCHITECT procalcitonin assay with established procalcitonin assay systems.Practical laboratory medicine · 2018Article
- The Role of Procalcitonin in the Diagnosis of Meningitis: A Literature Review.Journal of clinical medicine · 2018Review
- Expression of MMP-2 and TIMP-1 in cerebrospinal fluid and the correlation with dynamic changes of serum PCT in neonatal purulent meningitis.Experimental and therapeutic medicine · 2018Article
- Pleocytosis is not fully responsible for low CSF glucose in meningitis.Neurology(R) neuroimmunology & neuroinflammation · 2018Article
- Article
- Development and Validation of an Ultrasensitive Procalcitonin Sandwich Immunoassay.High-throughput · 2017Article
- Diagnostic Accuracy of Cerebrospinal Fluid Procalcitonin in Bacterial Meningitis Patients with Empiric Antibiotic Pretreatment.Journal of clinical microbiology · 2017Article
- Procalcitonin-guided diagnosis and antibiotic stewardship revisited.BMC medicine · 2017Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies have investigated the diagnostic accuracy of procalcitonin (PCT) levels in blood or cerebrospinal fluid (CSF) in bacterial meningitis (BM), but the results were heterogeneous. The aim of the present study was to ascertain the diagnostic accuracy of PCT as a marker for BM detection. A systematic search of the EMBASE, Scopus, Web of Science, and PubMed databases was performed to identify studies published before December 7, 2015 investigating the diagnostic accuracy of PCT for BM. The quality of the eligible studies was assessed using the revised Quality Assessment for Studies of Diagnostic Accuracy method. The overall diagnostic accuracy of PCT detection in CSF or blood was pooled using the bivariate model. Twenty-two studies involving 2058 subjects were included in this systematic review and meta-analysis. The overall specificities and sensitivities were 0.86 and 0.80 for CSF PCT, and 0.97 and 0.95 for blood PCT, respectively. Areas under the summary receiver operating characteristic curves were 0.90 and 0.98 for CSF PCT and blood PCT, respectively. The major limitation of this systematic review and meta-analysis was the small number of studies included and the heterogeneous diagnostic thresholds adopted by eligible studies. Our meta-analysis shows that PCT is a useful biomarker for BM diagnosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.