Observational studyMedicine2016
Effects of an Exhaustive Exercise on Motor Skill Learning and on the Excitability of Primary Motor Cortex and Supplementary Motor Area.
Observational study in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Changes in Physical Performance Following Operational Military Training: A Meta-Analysis.Sports medicine - open · 2025Pooled it
- A study on the effects of exercise training on cortical excitability in athletes: a meta-analysis based on TMS measurements.Frontiers in psychology · 2025Pooled it
- The role of deep breathing on stress.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Trial
- The impact of acute high-intensity activity on perceptual decision-making dynamics.Cognitive, affective & behavioral neuroscience · 2026Article
- Acute Skeletal Muscle Activation Through Physical Exercise and Its Effects on Cognitive Performance and Neurobiological Markers in Adults: A Scoping Review.Muscles (Basel, Switzerland) · 2026Review
- Time Estimation Following an Exhaustive Exercise.Journal of functional morphology and kinesiology · 2025Article
- Effects of Lactate on Corticospinal Excitability: A Scoping Review.International journal of exercise science · 2024Review
- Impact of muscle fatigue on anticipatory postural adjustments during gait initiation.Frontiers in physiology · 2024Article
- Attentive Processes and Blood Lactate in the Sambo.International journal of environmental research and public health · 2022Article
- Exploring intensity-dependent modulations in EEG resting-state network efficiency induced by exercise.European journal of applied physiology · 2021Article
- Effects of General Fatigue Induced by Exhaustive Exercise on Posture and Gait Stability of Healthy Young Men.Behavioral sciences (Basel, Switzerland) · 2021Article
- The Effects of High Mineral Alkaline Water Consumed Over Three Consecutive Days on Reaction Time Following Anaerobic Exercise - A Randomized Placebo-Controlled Crossover Pilot Study.Journal of human kinetics · 2021Article
- Influences of Blood Lactate Levels on Cognitive Domains and Physical Health during a Sports Stress. Brief Review.International journal of environmental research and public health · 2020Review
- Effects of a Bout of Intense Exercise on Some Executive Functions.International journal of environmental research and public health · 2020Article
- Effect of a Single Bout of Acute Aerobic Exercise at Moderate-to-Vigorous Intensities on Motor Learning, Retention and Transfer.Sports (Basel, Switzerland) · 2020Article
- Executive Functions During Submaximal Exercises in Male Athletes: Role of Blood Lactate.Frontiers in psychology · 2020Article
- HIIT the Road Jack: An Exploratory Study on the Effects of an Acute Bout of Cardiovascular High-Intensity Interval Training on Piano Learning.Frontiers in psychology · 2020Article
- Modulation of Distinct Intrinsic Resting State Brain Networks by Acute Exercise Bouts of Differing Intensity.Brain plasticity (Amsterdam, Netherlands) · 2019Article
- Sleep Deprivation and Physiological Responses. A Case Report.Journal of functional morphology and kinesiology · 2019Article
- The Effect of Aerobic Exercise on Speed and Accuracy Task Components in Motor Learning.Sports (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined, on 28 healthy adult subjects, the possible correlations of an exhaustive exercise, and the consequent high blood lactate levels, on immediate (explicit) and delayed (implicit) motor execution of sequential finger movements (cognitive task). Moreover, we determined with transcranial magnetic stimulation whether changes in motor performance are associated with variations in excitability of primary motor area (M1) and supplementary motor area (SMA). We observed that, after an acute exhaustive exercise, the large increase of blood lactate is associated with a significant worsening of both explicit and implicit sequential visuomotor task paradigms, without gender differences. We also found that, at the end of the exhaustive exercise, there is a change of excitability in both M1 and SMA. In particular, the excitability of M1 was increased whereas that of SMA decreased and, also in this case, without gender differences. These results support the idea that an increase of blood lactate after an exhaustive exercise appears to have a protective effect at level of primary cortical areas (as M1), although at the expense of efficiency of adjacent cortical regions (as SMA).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.