ArticlePloS one2016
Muscle Damage following Maximal Eccentric Knee Extensions in Males and Females.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Exercise-Induced Muscle Damage after a High-Intensity Interval Exercise Session: Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Influence of Structured Medium- and Long-Chain Triglycerides on Muscular Recovery Following Damaging Resistance Exercise.Nutrients · 2025Trial
- Effects of Tissue Flossing and Dynamic Stretching on Hamstring Muscles Function.Journal of sports science & medicine · 2020Trial
- Impaired microvascular reactivity after eccentric muscle contractions is not restored by acute ingestion of antioxidants or dietary nitrate.Physiological reports · 2019Trial
- Heterogenous quadriceps femoris inter-head but consistent intra-head rigidity changes after voluntary eccentric exercise-induced muscle damage.European journal of applied physiology · 2026Article
- Biochemical, immune, and endocrine biomarkers associated with exacerbated muscular response: insights from a field-based operational cohort study.Scientific reports · 2025Article
- Post-exercise creatine kinase variability: a literature review.Biochemia medica · 2025Review
- Effects of kinesiology taping timing on recovery in the lower limbs.Frontiers in physiology · 2025Article
- Association between Gray-Scale Ultrasound Imaging and Serological Creatine Kinase for Quantifying Exercise-Induced Muscle Damage: An Observational Study.Bioengineering (Basel, Switzerland) · 2023Article
- Recovery from Resistance Exercise in Older Adults: A Systematic Scoping Review.Sports medicine - open · 2023Article
- Effects of Eurycoma longifolia Jack supplementation on eccentric leg press exercise-induced muscle damage in rugby players.Biology of sport · 2023Article
- Training Load and Current Soreness Predict Future Delayed Onset Muscle Soreness in Collegiate Female Soccer Athletes.International journal of sports physical therapy · 2023Article
- Using Shear-Wave Elastography to Assess Exercise-Induced Muscle Damage: A Review.Sensors (Basel, Switzerland) · 2022Review
- Recovery from resistance exercise in older adults: a protocol for a scoping review.BMJ open sport & exercise medicine · 2022Article
- Musculoskeletal Health in Active Ambulatory Men with Cerebral Palsy and the Impact of Vitamin D.Nutrients · 2021Article
- Effect of Acute Static Stretching on the Activation Patterns Using High-Density Surface Electromyography of the Gastrocnemius Muscle during Ramp-Up Task.Sensors (Basel, Switzerland) · 2021Article
- Methodological Approach of the Iron and Muscular Damage: Female Metabolism and Menstrual Cycle during Exercise Project (IronFEMME Study).International journal of environmental research and public health · 2021Observational
- Resistance Training Acutely Impairs Agility and Spike-Specific Performance Measures in Collegiate Female Volleyball Players Returning from the Off-Season.International journal of environmental research and public health · 2020Article
- Pathophysiology of exercise-induced muscle damage and its structural, functional, metabolic, and clinical consequences.Physiological research · 2020Review
- Influence of the Menstrual Cycle on Blood Markers of Muscle Damage and Inflammation Following Eccentric Exercise.International journal of environmental research and public health · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate whether there is a sex difference in exercise induced muscle damage. MATERIALS AND
methodVastus Lateralis and patella tendon properties were measured in males and females using ultrasonography. During maximal voluntary eccentric knee extensions (12 reps x 6 sets), Vastus Lateralis fascicle lengthening and maximal voluntary eccentric knee extensions torque were recorded every 10° of knee joint angle (20-90°). Isometric torque, Creatine Kinase and muscle soreness were measured pre, post, 48, 96 and 168 hours post damage as markers of exercise induced muscle damage.
resultsPatella tendon stiffness and Vastus Lateralis fascicle lengthening were significantly higher in males compared to females (p<0.05). There was no sex difference in isometric torque loss and muscle soreness post exercise induced muscle damage (p>0.05). Creatine Kinase levels post exercise induced muscle damage were higher in males compared to females (p<0.05), and remained higher when maximal voluntary eccentric knee extension torque, relative to estimated quadriceps anatomical cross sectional area, was taken as a covariate (p<0.05).
conclusionBased on isometric torque loss, there is no sex difference in exercise induced muscle damage. The higher Creatine Kinase in males could not be explained by differences in maximal voluntary eccentric knee extension torque, Vastus Lateralis fascicle lengthening and patella tendon stiffness. Further research is required to understand the significant sex differences in Creatine Kinase levels following exercise induced muscle damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.