Evidence map›Paper›PMID 26985986›Full record

SynthesisThe Physician and sportsmedicine2016

Intra-articular treatment of knee osteoarthritis: from anti-inflammatories to products of regenerative medicine.

Masters M Richards, Joshua Shane Maxwell, Lihui Weng, Mathew G Angelos, Jafar Golzarian

Registry-linked trialOpen access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Physician and sportsmedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06032039 (Corticosteroid vs Platelet-Rich Plasma Intra-articular Injections in the Treatment of Knee Osteoarthritis in Patients Fifty Years and Older), which is not on this map. Cited by 88 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 6 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06032039 early_phase1unknown statusnot on this mapstarted 2023, after this paper: background citation

Corticosteroid vs Platelet-Rich Plasma Intra-articular Injections in the Treatment of Knee Osteoarthritis in Patients Fifty Years and Older: a Look at Pain and Functional Outcomes at a Single Institution.

TypeinterventionalSponsorThe University of The West IndiesRan2023 to 2025Enrolled160ConditionsKnee OsteoarthritisArmsTriamcinolone, Platelet Rich Plasma
3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 6 syntheses or guidelines pooled it, 169 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Regenerative Therapies for Basal Thumb Arthritis-A Systematic Review.International journal of molecular sciences · 2023
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. ITGB5 as a Potential Diagnostic Biomarker for Osteoarthritis.Journal of musculoskeletal & neuronal interactions · 2025
    Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Masters M Richardsa Department of Vascular and Interventional Radiology , University of Minnesota-School of Medicine , Minneapolis , MN , USA.
Joshua Shane Maxwellb Department of Family Medicine and Sports Medicine , University of Minnesota-School of Medicine , Minneapolis , MN , USA.
Lihui Wenga Department of Vascular and Interventional Radiology , University of Minnesota-School of Medicine , Minneapolis , MN , USA.
Mathew G Angelosc Department of Hematology, Oncology, and Transplantation , University of Minnesota-School of Medicine , Minneapolis , MN , USA.
Jafar Golzariana Department of Vascular and Interventional Radiology , University of Minnesota-School of Medicine , Minneapolis , MN , USA.
University of Minnesota · US

Funding

Deciphering Mechanisms of Early Human Hematoendothelial Development.F30DK107017 · NIDDK · UNIVERSITY OF MINNESOTA · PI ANGELOS, MATHEW · 2015 to 2017
$115k
NIDDK NIH HHS F30 DK107017
6 · The paper itself

Abstract

objectivesKnee osteoarthritis (OA) is a debilitating condition that may ultimately require total knee arthroplasty (TKA). Non-operative treatments are bracing, oral analgesics, physical therapy, and intra-articular knee injection (IAKI). The objective of this paper is to provide a systematic literature review regarding intra-articular treatment of knee OA and insight into promising new products of regenerative medicine that may eventually have a substantial effect on treatment.

methodsA literature search was executed using Medline, Cochrane, and Embase with keywords "knee osteoarthritis" and "injection." Specifically, 45 articles that discussed intra-articular knee injection using corticosteroids, hyaluronic acid, analgesics, local anesthetics, and newer products of regenerative medicine, such as platelet-rich plasma (PRP) and mesenchymal stem cells (MSC), were analyzed. Of these, eleven were level 1, three were level 2, twelve were level 3, two were level 4, and seventeen were level 5 evidence. Papers included animal models.

resultsLocal anesthetics have potential side effects and may only be effective for a few hours. Morphine and ketorolac may provide significant pain relief for 24 hours. Corticosteroids may give patients weeks to months of effective analgesia, but complications may occur, such as systemic hyperglycemia, septic arthritis, and joint degradation . Hyaluronic acid is a natural component of synovial fluid, but efficacy with respect to analgesia is controversial. Platelet-rich plasma formulations, autologous conditioned serum, autologous protein solution, and mesenchymal stem cell injections contain anti-inflammatory molecules and have been proposed to attenuate joint destruction or potentially remodel the joint.

conclusionsCurrently, knee OA treatment does not address the progressively inflammatory environment of the joint. More investigation is needed regarding products of regenerative medicine, but they may ultimately have profound implications in the way knee OA is managed.

Indexed as

Adrenal Cortex HormonesAnti-Inflammatory AgentsArthroplasty, Replacement, KneeBracesHumansHyaluronic AcidInjections, Intra-ArticularMesenchymal Stem Cell TransplantationOsteoarthritis, KneePainPlatelet-Rich PlasmaViscosupplementsAdrenal Cortex HormonesAnti-Inflammatory AgentsHyaluronic AcidViscosupplementscorticosteroidshyaluronic acidinjectionKnee osteoarthritisproducts of regenerative medicine

Identifiers

PMID26985986
PMCPMC4932822
OpenAlexW2298897662

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.