Evidence map›Paper›PMID 26985438›Full record

ArticleJournal of research in pharmacy practice

The risk factors for cytomegalovirus reactivation following stem cell transplantation.

Bahareh Valadkhani, Mona Kargar, Asieh Ashouri, Molouk Hadjibabaie, Kheirollah Gholami, Ardeshir Ghavamzadeh

Open access · goldAbstract read
In one paragraph

Article in Journal of research in pharmacy practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Assessing the significance of cytomegalovirus reactivation in recipients of allogeneic hematopoietic stem cell transplantation: a cohort study.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Bahareh ValadkhaniFaculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Mona KargarResearch Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran.
Asieh AshouriSchool of Health, Guilan University of Medical Sciences, Rasht, Iran.
Molouk HadjibabaieResearch Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran.
Kheirollah GholamiResearch Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran.
Ardeshir GhavamzadehDepartment of Hematology-Oncology, Hematology-Oncology and SCT Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Tehran University of Medical Sciences · IRGuilan University of Medical Sciences · IRShariati Hospital · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOpportunistic infections like cytomegalovirus (CMV) are among the primary causes of morbidity and mortality in patients undergoing hematipoetic stem cell transplantation (HSCT). This infection is frequently seen in early postengraftment period. So we determined to find the risk factors associated with CMV reactivation.

methodsWe retrospectively evaluated the medical records of 126 consecutive patients who underwent allogenic-HSCT from peripheral blood stem cells from August 2011 to February 2013 in Shariati Hospital. We included HSCT patients with 15 years of age or older, who survived at least 100 days after transplantation. CMV reactivation was detected based on the weekly PP65 assessment. Patients with 10 or more positive cells per 50,000 cells were defined as having high-level antigenemia.

findingsFrom 126 patients which included in this study, 76 were male (60%). CMV antigenemia was documented in 43 patients (34%). The median time to CMV infection was 40 days (range: 3-77) after transplantation. The incidence of high-level antigenemia during the first 100 days following HSCT was 11%.

conclusionWe found that the significant risk factor for CMV antigenemia in multivariate analysis was prior graft-versus-host disease (GVHD) experience and higher donor age. For high-level antigenemia, GVHD or duration of its treatment was significant determinant.

Indexed as

Allogeneic hematopoietic stem cell transplantationcytomegalovirus infectiongraft-versus-host disease

Identifiers

PMID26985438
PMCPMC4776549
OpenAlexW2277291064

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.