Evidence map›Paper›PMID 26985407›Full record

ArticleJournal of family medicine and primary care

Identifying gaps in research prioritization: The global burden of neglected tropical diseases as reflected in the Cochrane database of systematic reviews.

Soumyadeep Bhaumik, Chante Karimkhani, Christopher A Czaja, Hywel C Williams, Monica Rani, Mona Nasser, Lindsay N Boyers, Sergei Dmitruk, Robert P Dellavalle

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In one paragraph

Article in Journal of family medicine and primary care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Soumyadeep BhaumikJournal of Family Medicine and Primary Care, India; Cochrane Priority Setting Methods Group, United Kingdom.
Chante KarimkhaniCollege of Physicians and Surgeons, Columbia University New York, USA.
Christopher A CzajaDepartment of Family Medicine, University of Colorado School of Medicine, Aurora; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Colorado, USA.
Hywel C WilliamsCentre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK.
Monica RaniDepartment of Dermatology and Internal Medicine, Northwestern University, Chicago, IL, USA.
Mona NasserCochrane Priority Setting Methods Group, United Kingdom; Evidence Based Dentistry, Peninsula Dental School, Plymouth University, Plymouth, UK.
Lindsay N BoyersGeorgetown University School of Medicine, Washington, D.C., USA.
Sergei DmitrukDepartment of Family Medicine, University of Colorado School of Medicine, Aurora.
Robert P DellavalleDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Colorado, USA; Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora; Department of Dermatology, Denver Veterans Administration Hospital, Denver, Colorado, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeglected tropical diseases (NTDs) impact disadvantaged populations in resource-scarce settings. Availability of synthesized evidence is paramount to end this disparity. The aim of the study was to determine whether NTD systematic reviews or protocols in the Cochrane Database of Systematic Reviews (CDSR) reflect disease burden.

methodsTwo authors independently searched the CDSR for reviews/protocols regarding the NTDs diseases. Each review or protocol was classified to a single NTD category. Any discrepancy was solved by consensus with third author. NTD systematic review or protocol from CDSR were matched with disability-adjusted life year (DALY) metrics from the Global Burden of Disease 2010 Study. Spearman's rank correlation coefficient and associated P values were used to assess for correlation between the number of systematic reviews and protocols and the %2010 DALY associated with each NTD.

resultsOverall, there was poor correlation between CDSR representation and DALYs. Yellow fever, echinococcus, onchocerciasis, and schistosomiasis representation was well-aligned with DALY. Leprosy, trachoma, dengue, leishmaniasis, and Chagas disease representation was greater, while cysticercosis, human African trypanosomiasis, ascariasis, lymphatic filariasis, and hookworm representation was lower than DALY. Three of the 18 NTDs had reviews/protocols of diagnostic test accuracy.

conclusionsOur results indicate the need for increased prioritization of systematic reviews on NTDs, particularly diagnostic test accuracy reviews.

Indexed as

Disability-adjusted life yeardisease burdenneglected tropical diseasesresearch prioritizationsystematic review

Identifiers

PMID26985407
PMCPMC4776600

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.