Evidence map›Paper›PMID 26985401›Full record

ArticleInformatics (MDPI)2014

Molecular imaging of bacterial infections in vivo: the discrimination of infection from inflammation.

Heather Eggleston, Peter Panizzi

Abstract read
In one paragraph

Article in Informatics (MDPI), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Understanding bacterial biofilms: From definition to treatment strategies.Frontiers in cellular and infection microbiology · 2023
    Pooled it
  2. Article
  3. EJNMMI radiopharmacy and chemistry · 2023
    Article
  4. Metals to combat antimicrobial resistance.Nature reviews. Chemistry · 2023
    Review
  5. Review
  6. Article
  7. Imaging Inflammation and Infection in the Gastrointestinal Tract.International journal of molecular sciences · 2019
    Review
  8. Neurotheranostics as personalized medicines.Advanced drug delivery reviews · 2019
    Review
  9. Article
  10. Article
  11. Validation of 2-Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018
    Article
  12. Article
  13. Siderophores for molecular imaging applications.Clinical and translational imaging · 2017
    Review
  14. Review
  15. Article
  16. Article
  17. Scaffold-based anti-infection strategies in bone repair.Annals of biomedical engineering · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Heather EgglestonDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849.
Peter PanizziDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849.

Funding

Random Shear Shuttle BAC Libraries for Antimicrobial Discovery from Soil MetagenoR44AI085840 · NIAID · LUCIGEN CORPORATION · PI LI, XING-CONG, LILES, MARK R · 2012 to 2014
$2.6M
Pathogen specific imaging of endocarditisR01HL114477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS, PANIZZI, PETER ROLF · 2013 to 2016
$1.7M
Pathobiology of Staphyloccocus areus EndocarditisR00HL094533 · NHLBI · AUBURN UNIVERSITY AT AUBURN · PI PANIZZI, PETER ROLF · 2011 to 2013
$719k
Pathobiology of Staphyloccocus areus EndocarditisK99HL094533 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI PANIZZI, PETER ROLF · 2009 to 2010
$273k
NHLBI NIH HHS K99 HL094533NHLBI NIH HHS R00 HL094533NHLBI NIH HHS R01 HL114477NIAID NIH HHS R44 AI085840
6 · The paper itself

Abstract

Molecular imaging by definition is the visualization of molecular and cellular processes within a given system. The modalities and reagents described here represent a diverse array spanning both pre-clinical and clinical applications. Innovations in probe design and technologies would greatly benefit therapeutic outcomes by enhancing diagnostic accuracy and assessment of acute therapy. Opportunistic pathogens continue to pose a worldwide threat, despite advancements in treatment strategies, which highlights the continued need for improved diagnostics. In this review, we present a summary of the current clinical protocol for the imaging of a suspected infection, methods currently in development to optimize this imaging process, and finally, insight into endocarditis as a model of infectious disease in immediate need of improved diagnostic methods.

Indexed as

EndocarditisInfectionInflammationMolecular ImagingStaphylococcus aureus

Identifiers

PMID26985401
PMCPMC4790455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.