ArticleSAGE open medicine2016
Medication regimen complexity and readmissions after hospitalization for heart failure, acute myocardial infarction, pneumonia, and chronic obstructive pulmonary disease.
Article in SAGE open medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Evaluation of medication regimen complexity and rehospitalization in older adults with chronic kidney disease: a retrospective cohort study.BMC geriatrics · 2026Article
- Changes in Medication Complexity and Post-Hospitalization Outcomes in Older Adults Hospitalized for Heart Failure.Drugs & aging · 2025Article
- Implications of the medication regimen complexity index score on hospital readmissions in elderly patients with heart failure: a retrospective cohort study.BMC geriatrics · 2023Article
- Assessment of Medication Regimen Complexity of COPD Regimens in Individuals Visiting Community Pharmacies.International journal of chronic obstructive pulmonary disease · 2023Article
- Medication Complexity Among Older Adults with HF: How Can We Assess Better?Drugs & aging · 2022Review
- Evaluating the Medication Regimen Complexity Score as a Predictor of Clinical Outcomes in the Critically Ill.Journal of clinical medicine · 2022Article
- Medication regimen complexity of coronary artery disease patients.Einstein (Sao Paulo, Brazil) · 2021Article
- Article
- Characterization of the medication regimen complexity index in high-utilizer, adult psychiatric patients.The mental health clinician · 2020Article
- Impact of Medication Regimen Simplification on Medication Administration Times and Health Outcomes in Residential Aged Care: 12 Month Follow Up of the SIMPLER Randomized Controlled Trial.Journal of clinical medicine · 2020Article
- Rehospitalization for pneumonia after first pneumonia admission: Incidence and predictors in a population-based cohort study.PloS one · 2020Article
- Treatment burden, clinical outcomes, and comorbidities in COPD: an examination of the utility of medication regimen complexity index in COPD.International journal of chronic obstructive pulmonary disease · 2017Article
- Medication regimen complexity in ambulatory older adults with heart failure.Clinical interventions in aging · 2017Article
- Associations of medication regimen complexity with medication adherence and clinical outcomes in patients with chronic obstructive pulmonary disease: a prospective study.Therapeutic advances in respiratory diseaseArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesReadmission rate is increasingly being viewed as a key indicator of health system performance. Medication regimen complexity index scores may be predictive of readmissions; however, few studies have examined this potential association. The primary objective of this study was to determine whether medication regimen complexity index is associated with all-cause 30-day readmission after admission for heart failure, acute myocardial infarction, pneumonia, or chronic obstructive pulmonary disease.
methodsThis study was an institutional review board-approved, multi-center, case-control study. Patients admitted with a primary diagnosis of heart failure, acute myocardial infarction, pneumonia, or chronic obstructive pulmonary disease were randomly selected for inclusion. Patients were excluded if they discharged against medical advice or expired during their index visit. Block randomization was utilized for equal representation of index diagnosis and site. Discharge medication regimen complexity index scores were compared between subjects with readmission versus those without. Medication regimen complexity index score was then used as a predictor in logistic regression modeling for readmission.
resultsSeven hundred and fifty-six patients were randomly selected for inclusion, and 101 (13.4%) readmitted within 30 days. The readmission group had higher medication regimen complexity index scores than the no-readmission group (p < 0.01). However, after controlling for demographics, disease state, length of stay, site, and medication count, medication regimen complexity index was no longer a significant predictor of readmission (odds ratio 0.99, 95% confidence interval 0.97-1.01) or revisit (odds ratio 0.99, 95% confidence interval 0.98-1.02).
conclusionThere is little evidence to support the use of medication regimen complexity index in readmission prediction when other measures are available. Medication regimen complexity index may lack sufficient sensitivity to capture an effect of medication regimen complexity on all-cause readmission.
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