ArticleInternational journal of fertility & sterility
Correlation of Serum CA-125 and Progesterone Levels with Ultrasound Markers in The Prediction of Pregnancy Outcome in Threatened Miscarriage.
Article in International journal of fertility & sterility. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Pooled it
- Pooled it
- Unlocking uterine biology at home: a validated system for DNA, RNA, and microbial analysis from menstrual effluence.medRxiv : the preprint server for health sciences · 2025Article
- Evaluation of Pregnancy Risks in Women with Subchorionic Hematoma Using Machine Learning Models.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- A prospective study to evaluate whether serum kisspeptin is a marker predictive of the first-trimester miscarriage of women who conceive in IVF.Journal of assisted reproduction and genetics · 2024Article
- Significance of dynamically monitoring serum estrogen and β-human chorionic gonadotropin in early pregnancy assessment.Journal of clinical laboratory analysis · 2021Article
- Evidence from three cohort studies on the expression of MUC16 around the time of implantation suggests it is an inhibitor of implantation.Journal of assisted reproduction and genetics · 2020Article
- Baseline Levels of Serum Progesterone and the First Trimester Pregnancy Outcome in Women with Threatened Abortion: A Retrospective Cohort Study.BioMed research international · 2020Article
- Cytokines in relation to hCG are significantly altered in asymptomatic women with miscarriage - a pilot study.Reproductive biology and endocrinology : RB&E · 2018Article
- Spontaneous miscarriage in first trimester pregnancy is associated with altered urinary metabolite profile.BBA clinical · 2017Article
- Serum periostin levels in early in pregnancy are significantly altered in women with miscarriage.Reproductive biology and endocrinology : RB&E · 2017Article
- Validation of serum progesterone <35nmol/L as a predictor of miscarriage among women with threatened miscarriage.BMC pregnancy and childbirth · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to evaluate the relationship between ultrasonographic findings and serum progesterone and cancer antigen-125 (CA-125) levels in threatened miscarriage and to predict pregnancy outcome. MATERIALS AND
methodsIn a prospective comparative case-control study, serum CA-125 and progesterone levels were measured for 100 pregnant women with threatened miscarriage who attended the outpatient clinic or the causality department of Obstetrics and Gynecology at Kasr El-Aini Hospital, Giza, Egypt, during the period from March 2013 to October 2013. Ultrasound was performed for fetal viability, crown-rump length (CRL), gestational sac diameter (GSD) and fetal heart rate (FHR). The patients were followed up and divided into two groups based on the outcome: 20 women who miscarried (group 1), and 80 women who continued pregnancy (group 2). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall accuracy were tested for CA-125 and progesterone levels in prediction of the pregnancy outcome. Correlation of these chemical markers with the ultrasound markers was also examined.
resultsIn the group that miscarried, CA-125 level was significantly higher (P<0.001) and serum progesterone level was significantly lower (P<0.001). For prediction of the outcome of pregnancy, the cut-off limit of 31.2 IU/ml for CA-125 level yielded sensitivity, specificity and an overall accuracy of 96.2, 100 and 99.4% respectively. The cut-off limit of 11.5 ng/ml for progesterone level yielded sensitivity, specificity and an overall accuracy of 97.5, 100 and 99.8% respectively. CA-125 level had a negative correlation with progesterone level and FHR levels (r=-0.716, P<0.001) and (r=-0.414, P<0.001) respectively. Serum progesterone level correlated with GSD (r=0.521, P<0.001) and with CRL (r=0.407, P<0.001) and FHR (r=0.363, P<0.001). CA-125 level was significantly higher in the group that showed hematoma as compared with the group without hematoma (P<0.001). Also, serum progesterone level was significantly lower in the group that showed hematoma as compared with the group without hematoma (P=0.017).
conclusionSerum CA-125 and progesterone levels are valid early predictors of the outcome of pregnancy in women with threatened miscarriage. They are correlated with some ultrasonographic markers (GSD, CRL, and FHR).
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