ReviewJournal of clinical medicine research2016
Use of Sodium Bicarbonate in Cardiac Arrest: Current Guidelines and Literature Review.
Review in Journal of clinical medicine research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Esmolol in the management of refractory ventricular fibrillation: a systematic review and meta-analysis.Acute and critical care · 2026Article
- Localized antithrombotic but minimal systemic coagulation effects of sodium bicarbonate in mechanical circulatory support.Journal of thrombosis and thrombolysis · 2026Article
- Prehospital Blood pH Testing and Survival in Non-Traumatic Out-of-Hospital Cardiac Arrest: Insights from a Thai EMS Unit.Open access emergency medicine : OAEM · 2026Article
- Effects of Initial Lactate Levels and 24-h Lactate Clearance on Mortality in Post-Cardiac Arrest Patients: Insights from the Multicenter TIMECARD Registry.International journal of medical sciences · 2026Article
- Point-of-Care Testing (POCT) for Blood Gas and Electrolyte Analysis in Out-of-Hospital Cardiac Arrests' Management; a Cross-sectional Study.Archives of academic emergency medicine · 2025Article
- Sodium Bicarbonate In In-Hospital and Out-of-Hospital Cardiac Arrest: A Systematic Literature Review.Cureus · 2024Review
- The early change in pH values after out-of-hospital cardiac arrest is not associated with neurological outcome at hospital discharge.Resuscitation plus · 2024Article
- Epinephrine in Cardiac Arrest: Identifying a Potential Limit for Resuscitation.The western journal of emergency medicine · 2023Article
- A Review of Bicarbonate Use in Common Clinical Scenarios.The Journal of emergency medicine · 2023Review
- Review
- A retrospective study on the therapeutic effects of sodium bicarbonate for adult in-hospital cardiac arrest.Scientific reports · 2021Article
- Antidotal Sodium Bicarbonate Therapy: Delayed QTc Prolongation and Cardiovascular Events.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2021Observational
- Early Administration of Glutamine Protects Cardiomyocytes from Post-Cardiac Arrest Acidosis.BioMed research international · 2016Article
- Efficacy of bicarbonate therapy for adults with cardiac arrest: A systematic review and meta-analysis of randomized-controlled trials.Turkish journal of emergency medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the review was to summarize the literature over the last 25 years regarding bicarbonate administration in out-of-hospital cardiac arrest. A PubMed search was conducted using the terms "bicarbonates" and "cardiac arrest", limited to human studies and reviews published in English (or at least with a meaningful abstract in English) in the last 25 years. Clinical and experimental data raised questions regarding the safety and effectiveness of sodium bicarbonate (SB) administration during cardiac arrest. Earlier advanced cardiac life support (ACLS) guidelines recommended routine bicarbonate administration as part of the ACLS algorithm, but recent guidelines no longer recommend its use. The debate in the literature is ongoing, but at the present time, SB administration is only recommended for cardiac arrest related to hypokalemia or overdose of tricyclic antidepressants. Several studies challenge the assumption that bicarbonate administration is beneficial for treatment of acidosis in cardiac arrest. At the present time, there is a trend against using bicarbonates in cardiac arrest, and this trend is supported by guidelines published by professional societies and organizations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.