ArticleIndian journal of psychiatry
Circadian clock gene aryl hydrocarbon receptor nuclear translocator-like polymorphisms are associated with seasonal affective disorder: An Indian family study.
Article in Indian journal of psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Circadian rhythm, epigenetics and disease interaction.Global medical genetics · 2025Review
- Investigation of the effects of oxidative stress, inflammation on the pathway of tryptophan/kynurenine in OCD.Acta neuropsychiatrica · 2023Article
- Circadian Gene Polymorphisms Associated with Breast Cancer Susceptibility.International journal of molecular sciences · 2019Article
- Sleep Disturbance in Bipolar Disorder: Neuroglia and Circadian Rhythms.Frontiers in psychiatry · 2019Review
- Association of genetic variants with fatigue in patients with malignant glioma.Neuro-oncology practice · 2018Article
- Evidences of Polymorphism Associated with Circadian System and Risk of Pathologies: A Review of the Literature.International journal of endocrinology · 2016Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
BACKGROUND AND
aimPolymorphisms in aryl hydrocarbon receptor nuclear translocator-like (ARNTL) gene, the key component of circadian clock manifests circadian rhythm abnormalities. As seasonal affective disorder (SAD) is associated with disrupted circadian rhythms, the main objective of this study was to screen an Indian family with SAD for ARNTL gene polymorphisms. MATERIALS AND
methodsIn this study, 30 members of close-knit family with SAD, 30 age- and sex-matched controls of the same caste with no prior history of psychiatric illness and 30 age- and sex-matched controls belonging to 17 different castes with no prior history of psychiatric illness were genotyped for five different single nucleotide polymorphisms (SNPs) in ARNTL gene by TaqMan allele-specific genotyping assay. STATISTICAL ANALYSIS: Statistical significance was assessed by more powerful quasi-likelihood score test-XM.
resultsMost of the family members carried the risk alleles and we observed a highly significant SNP rs2279287 (A/G) in ARNTL gene with an allelic frequency of 0.75.
conclusionsPolymorphisms in ARNTL gene disrupt circadian rhythms causing SAD and genetic predisposition becomes more deleterious in the presence of adverse environment.
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