Evidence map›Paper›PMID 26984977›Full record

ReviewJournal of clinical microbiology2016

Laboratory Diagnosis of Mycobacterium tuberculosis Infection and Disease in Children.

James J Dunn, Jeffrey R Starke, Paula A Revell

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  3. Screening tests for active pulmonary tuberculosis in children.The Cochrane database of systematic reviews · 2021
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

James J DunnDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA jjdunn@texaschildrens.org.
Jeffrey R StarkeDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Paula A RevellDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diagnosis of tuberculosis in children is challenging; even with advanced technologies, the diagnosis is often difficult to confirm microbiologically in part due to the paucibacillary nature of the disease. Clinical diagnosis lacks standardization, and traditional and molecular microbiologic methods lack sensitivity, particularly in children. Immunodiagnostic tests may improve sensitivity, but these tests cannot distinguish tuberculosis disease from latent infection and some lack specificity. While molecular tools like Xpert MTB/RIF have advanced our ability to detect Mycobacterium tuberculosis and to determine antimicrobial resistance, decades old technologies remain the standard in most locales. Today, the battle against this ancient disease still poses one of the primary diagnostic challenges in pediatric laboratory medicine.

Indexed as

AdolescentChildChild, PreschoolClinical Laboratory TechniquesDiagnostic Tests, RoutineHumansInfantInfant, NewbornMolecular Diagnostic TechniquesMycobacterium tuberculosisTuberculosis

Identifiers

PMID26984977
PMCPMC4879301

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.