Observational studyInteractive cardiovascular and thoracic surgery2016
Predictive value of high-sensitivity troponin T in addition to EuroSCORE II in cardiac surgery.
Observational study in Interactive cardiovascular and thoracic surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Trial
- The Role of Markers of Myocardial Damage in Predicting Postoperative Multiple Organ Dysfunction Syndrome and 30-Day Mortality in Patients Undergoing Heart Valve Surgery.Journal of clinical medicine · 2026Article
- Association of MMP-9 and TIMP-1 concentration with neurological outcome after cardiac arrest and resuscitation - a substudy of the COMACARE trial.Resuscitation plus · 2026Article
- High-Sensitivity Troponin T as a Predictor of Prolonged Intensive Care Unit Stay and Worse Treatment Outcomes in Patients Undergoing Heart Valve Surgery.Journal of clinical medicine · 2025Article
- Prognostic Value of Cardiac Biomarkers in Patients Undergoing On-Pump Coronary Artery Bypass Grafting: A Cohort Study in An Iranian Population.Journal of chest surgery · 2025Article
- Timing and threshold of high sensitive troponin T measurement for the prediction of mortality after cardiac surgery: a retrospective cohort analysis.Intensive care medicine experimental · 2023Article
- Defining Peri-Operative Myocardial Injury during Cardiac Surgery Using High-Sensitivity Troponin T.Journal of clinical medicine · 2023Article
- Association of early elevated cardiac troponin I concentration and longitudinal change after off-pump coronary artery bypass grafting and adverse events: a prospective cohort study.Journal of thoracic disease · 2020Article
- Predictive ability of EuroSCORE II integrating cardiactroponin T in patients undergoing OPCABG.BMC cardiovascular disorders · 2020Observational
- High-sensitivity C-reactive protein as a prognostic marker in patients undergoing valve surgery.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2020Article
- Usefulness of FRAIL Scale in Heart Valve Diseases.Clinical interventions in aging · 2020Article
- The usefulness of N-terminal prohormone brain natriuretic peptide in patients undergoing aortic valve replacement.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2019Article
- Pathogenesis and Management of Acute Kidney Injury in Patients with Nephrotic Syndrome Due to Primary Glomerulopathies.Medicina (Kaunas, Lithuania) · 2019Review
- The origin of plasma neutrophil gelatinase-associated lipocalin in cardiac surgery.BMC nephrology · 2019Observational
- Performance of the EuroSCORE II and the Society of Thoracic Surgeons score in patients undergoing aortic valve replacement for aortic stenosis.Journal of thoracic disease · 2019Article
- Postoperative high-sensitivity troponin T as a predictor of sudden cardiac arrest in patients undergoing cardiac surgery.Cardiology journal · 2019Article
- The usefulness of selected biomarkers in aortic regurgitation.Cardiology journal · 2019Article
- High-sensitivity troponin T release profile in off-pump coronary artery bypass grafting patients with normal postoperative course.BMC cardiovascular disorders · 2018Article
- Does Preoperative Troponin Level Impact Outcomes After Coronary Artery Bypass Grafting?The Annals of thoracic surgery · 2018Article
- Prognostic Value of Early Postoperative Troponin T in Patients Undergoing Coronary Artery Bypass Grafting.Journal of the American Heart Association · 2018Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPlasma troponins, measured by fourth-generation assays, are associated with increased mortality and morbidity after cardiac surgery. They also offer predictive information in addition to EuroSCORE, a widely used risk model after cardiac surgery. However, preoperatively measured troponin has provided no additional information to postoperative values. Whether these facts hold true also for the high-sensitivity fifth-generation troponin assay and the better calibrated risk model, EuroSCORE II, is unknown. We hypothesized that preoperative and/or postoperative high-sensitivity troponin T (hs-TnT) would increase the predictive value of EuroSCORE II.
methodsConsecutive coronary artery bypass grafting (CABG) and other cardiac surgical patients were prospectively enrolled in a university hospital. Plasma samples and EuroSCORE II variables were collected. The primary and secondary end-points were 180-day mortality and any major adverse event within 30 days, and 961-day mortality. The data were analysed by Kaplan-Meier survival curves, regression analyses, receiver operator characteristic curves and decision curve analysis.
resultsMortality rates in 180 days were 3.5% (15/428) in CABG and 6.4% (14/220) in other cardiac surgical patients. Survival curves differed only in patients with not only high postoperative hs-TnT value (>500 ng/l), but also high preoperative hs-TnT value (>14 ng/l), compared with patients with both hs-TnT values low. Adding hs-TnT to EuroSCORE II improved the prediction of 180-day mortality in other cardiac surgical patients (maximum net benefit of 1.5%), but not in CABG patients. Regarding major adverse events, adding hs-TnT to EuroSCORE II improved the prediction in both CABG patients and other cardiac surgical patients (maximum net benefits of 3 and 7%).
conclusionsElevated postoperative hs-TnT was predictive of mortality only when combined with elevated preoperative hs-TnT. Hs-TnT measurements added information to the EuroSCORE II regarding major adverse events in all cardiac surgical patients and regarding 180-day mortality in non-CABG patients.
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