Evidence map›Paper›PMID 26984929›Full record

ArticleJournal of clinical pathology2016

TGFα expression in myeloid malignancies.

Simon Kavanagh, Bob Mirzai, Kathy Fuller, Wendy N Erber

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Simon KavanaghPathology and Laboratory Medicine, The University of Western Australia, Crawley, Western Australia, Australia PathWest Laboratory Medicine, Nedlands, Western Australia, Australia.ORCID http://orcid.org/0000-0001-5809-2882
Bob MirzaiPathology and Laboratory Medicine, The University of Western Australia, Crawley, Western Australia, Australia PathWest Laboratory Medicine, Nedlands, Western Australia, Australia.
Kathy FullerPathology and Laboratory Medicine, The University of Western Australia, Crawley, Western Australia, Australia.
Wendy N ErberPathology and Laboratory Medicine, The University of Western Australia, Crawley, Western Australia, Australia PathWest Laboratory Medicine, Nedlands, Western Australia, Australia.
The University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTransforming growth factor α (TGFα) is a peptide growth factor known to be expressed in normal haemopoiesis. It is also expressed in a range of epithelial neoplasms but has not been assessed in haemopoietic malignancies. We have performed an immunohistochemical evaluation of TGFα in acute and chronic myeloid malignancies.

methodsTGFα expression was semiquantitatively assessed in 69 normal bone marrow trephines and 157 cases of myeloid malignancy using an immunohistochemical approach.

resultsBlast cells of myeloid origin in acute myeloid leukaemia (AML), myelodysplasia and accelerated and blast phases of chronic myeloid leukaemia (CML) were TGFα positive. In acute promyelocytic leukaemia the neoplastic cells had significantly weaker TGFα expression than seen in other forms of AML. The blast cells in CML-accelerated and blast phases were positive with similar expression to AML.

conclusionsTGFα is expressed in neoplastic myeloblasts and could, therefore, be used as blast cell biomarker in diagnostic haematopathology. In addition, TGFα immunohistochemistry may be of use in identifying a therapeutic target.

Indexed as

BiomarkersBone MarrowHematopoiesisHumansImmunohistochemistryLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myeloid, AcuteLeukemia, Promyelocytic, AcuteLeukocytesMyelodysplastic SyndromesMyeloproliferative DisordersTransforming Growth Factor alphaBiomarkersTGFA protein, humanTransforming Growth Factor alphaHAEMATO-ONCOLOGYHAEMATOPATHOLOGYIMMUNOHISTOCHEMISTRY

Identifiers

PMID26984929
PMCPMC4893134
OpenAlexW2308946838

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.