ArticleJournal of the American Society of Nephrology : JASN2016
Autoantibodies Targeting a Collecting Duct-Specific Water Channel in Tubulointerstitial Nephritis.
Article in Journal of the American Society of Nephrology : JASN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- NFAT5: a stress-related transcription factor with multiple functions in health and disease.Cell stress · 2025Review
- Potential Role of Antibodies against Aquaporin-1 in Patients with Central Nervous System Demyelination.International journal of molecular sciences · 2023Review
- Aquaporins in Urinary System.Advances in experimental medicine and biology · 2023Article
- A gene-centric approach to biomarker discovery identifies transglutaminase 1 as an epidermal autoantigen.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The natural history of 21-hydroxylase autoantibodies in autoimmune Addison's disease.European journal of endocrinology · 2021Article
- Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'.eLife · 2019Article
- Aquaporins in Renal Diseases.International journal of molecular sciences · 2019Review
- Aquaporin-Targeted Therapeutics: State-of-the-Field.Advances in experimental medicine and biology · 2017Review
- Novel Findings into AIRE Genetics and Functioning: Clinical Implications.Frontiers in pediatrics · 2016Review
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Authors and funding
21 authors at 12 institutions in 6 countries.
Funding
Abstract
Tubulointerstitial nephritis is a common cause of kidney failure and may have diverse etiologies. This form of nephritis is sometimes associated with autoimmune disease, but the role of autoimmune mechanisms in disease development is not well understood. Here, we present the cases of three patients with autoimmune polyendocrine syndrome type 1 who developed tubulointerstitial nephritis and ESRD in association with autoantibodies against kidney collecting duct cells. One of the patients developed autoantibodies targeting the collecting duct-specific water channel aquaporin 2, whereas autoantibodies of the two other patients reacted against the HOXB7 or NFAT5 transcription factors, which regulate the aquaporin 2 promoter. Our findings suggest that tubulointerstitial nephritis developed in these patients as a result of an autoimmune insult on the kidney collecting duct cells.
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Registered trials
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