ArticleGenetica2016
Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry.
Article in Genetica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Pharmacogenomics of Major Depressive Disorder in Indigenous Amazonian Populations.Clinical pharmacology and therapeutics · 2026Article
- Analysis of genomic ancestry and characterization of a new variant in MPS type VII.Orphanet journal of rare diseases · 2025Article
- Is there are relationship between polymorphisms TSHR gene frequencies and genetic ancestry markers in patients with Primary Congenital Hypothyroidism?Genetics and molecular biology · 2025Article
- Mitochondrial variants of complex I genes associated with leprosy clinical subtypes.Scientific reports · 2024Article
- Molecular Profile of Variants Potentially Associated with Severe Forms of COVID-19 in Amazonian Indigenous Populations.Viruses · 2024Article
- Involvement of SYCP2L and TDRD3 gene variants on ovarian reserve and reproductive outcomes: a cross-sectional study.JBRA assisted reproduction · 2023Article
- Investigation ofBiomedicines · 2023Article
- Influence of Genetic Variations in miRNA and Genes Encoding Proteins in the miRNA Synthesis Complex on Toxicity of the Treatment of Pediatric B-Cell ALL in the Brazilian Amazon.International journal of molecular sciences · 2023Article
- Association between Polymorphism of GenesGenes · 2023Article
- Heterogeneity in disease resistance and the impact of antibiotics in the US.Economics and human biology · 2022Article
- The Genomic Profile Associated with Risk of Severe Forms of COVID-19 in Amazonian Native American Populations.Journal of personalized medicine · 2022Article
- The Role ofGenes · 2022Article
- Article
- Variants in theNutrients · 2022Article
- Association of the rs4646994 inTranslational medicine communications · 2022Article
- Genetic Variants of MicroRNA and DROSHA Genes in Association With the Risk of Tuberculosis in the Amazon Population.Frontiers in genetics · 2022Article
- Influence of Polymorphism on theJournal of personalized medicine · 2021Article
- Ancestral genetic legacy of the extant population of Argentina as predicted by autosomal and X-chromosomal DIPs.Molecular genetics and genomics : MGG · 2021Article
- Genetic Diversity of Drug-Related Genes in Native Americans of the Brazilian Amazon.Pharmacogenomics and personalized medicine · 2021Article
- Association between theGenes · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ancestry information can be useful in investigations of diseases with a genetic or infectious background. As the Brazilian population is highly admixed physical traits tend to be poor indicators of ancestry. The assessment of ancestry by ancestry informative markers (AIMs) can exclude the subjectivity of self-declared ethnicity and reported family origin. We aimed to evaluate the reliability of self-reported ethnicity or reported family origin as indicators of genomic ancestry in a female population from the Southeast of Brazil. Two cohorts were included: 404 women asked to self-report their ethnicity (Pop1) and 234 women asked to report their family's origin (Pop2). Identification of AIMs was performed using a panel of 61 markers and results were plotted against parental populations-Amerindian, Western European and Sub-Saharan African-using Structure v2.3.4. In Pop1 57.4 % of women self-reported as white, 34.6 % as brown and 8.0 % as black. Median global European, Amerindian and African contributions were 66.8, 12.6 and 16.6 %. In Pop2, 66.4 % of women declared European origin, 23.9 % African origin and 26.9 % Amerindian. Median global European, Amerindian and African contributions were 80.8, 7.3 and 7.6 %, respectively. Only 31.0 and 21.0 % of the global variation in African and European contributions, respectively, could be explained by self-reported ethnicity and reported family origin only accounted for 20.0 and 5.0 % of the variations observed in African and European ancestries, respectively. Amerindian ancestry did not influence self-reported ethnicity or declared family origin. Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry in these Brazilian populations.
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