Evidence map›Paper›PMID 26984807›Full record

Trial reportChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2016

Nightly oral administration of topiramate for benign childhood epilepsy with centrotemporal spikes.

Chunrong Liu, Mei Song, Jiwen Wang

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chunrong LiuDepartment of Pediatrics, People's Hospital of Yucheng, Yucheng, 251200, China.
Mei SongDepartment of Pediatrics, People's Hospital of Yucheng, Yucheng, 251200, China.
Jiwen WangDepartment of Neurology, Shanghai Children's Medical Center, Shanghai Jiaotong University, Shanghai, 200127, China. docjiwenwang@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study was to explore the feasibility of nightly oral administration of topiramate for treating benign childhood epilepsy with centrotemporal spikes (BECTS).

methodsEighty-five children with BECTS receiving topiramate treatment were randomly divided into A group (44 patients) and B group (41 patients). In A group, topiramate was orally administrated once a night, with a final dose of 2 mg/kg/day. In B group, topiramate was orally administrated twice a day, with a final dose of 4 mg/kg/day. At the end of the 12-month follow-up period, clinical efficacy, changes in electroencephalographic (EEG) activity, and adverse reactions were analyzed.

resultsThere was no significant difference in overall efficacy rate, percentages of patients achieving seizure free, or changes in EEG activity between the two groups (P > 0.05). The rate of adverse reactions for A group was 9.1 %, which was significantly lower than the 29.3 % for B group (χ (2) = 4.262, P < 0.05).

conclusionNightly oral administration of topiramate is a feasible strategy for the treatment of BECTS, with the advantages of comparable efficacy, convenience, and fewer adverse reactions.

Indexed as

Administration, OralAdolescentAnticonvulsantsBrainChildChild, PreschoolDrug Administration ScheduleElectroencephalographyEpilepsy, RolandicFemaleFructoseHumansMaleTopiramateTreatment OutcomeAnticonvulsantsFructoseTopiramateBenign childhood epilepsyTherapyTopiramateTreatment

Identifiers

PMID26984807

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.