Evidence map›Paper›PMID 26984771›Full record

ArticleCritical care (London, England)2016

Low Plasma Levels of Adiponectin Do Not Explain Acute Respiratory Distress Syndrome Risk: a Prospective Cohort Study of Patients with Severe Sepsis.

Jessica A Palakshappa, Brian J Anderson, John P Reilly, Michael G S Shashaty, Ryo Ueno, Qufei Wu, Caroline A G Ittner, Anna Tommasini, Thomas G Dunn, Dudley Charles and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Jessica A PalakshappaDivision of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA. jessica.palakshappa@uphs.upenn.edu.
Brian J AndersonDivision of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
John P ReillyDivision of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Michael G S ShashatyDivision of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Ryo UenoGraduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 1130033, Japan.
Qufei WuDivision of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Caroline A G IttnerDivision of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Anna TommasiniDivision of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Thomas G DunnDivision of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Dudley CharlesDivision of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Altaf KaziDivision of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Jason D ChristieDivision of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Nuala J MeyerDivision of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Hospital of the University of Pennsylvania · USPennsylvania Hospital · USUniversity of Pennsylvania · USThe University of Tokyo · JP

Funding

Cardiology & pulmonary research training grantT32HL007891 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Jason D Christie · 1998 to 2026
$12.0M
Neurologic Clinical Epidemiology Training ProgramT32NS061779 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Andrea Lauren Christman Schneider, Allison Willis · 2008 to 2026
$4.6M
Obesity, Inflammation, and Lung Injury After Lung TransplantationR01HL114626 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHRISTIE, JASON D, LEDERER, DAVID J. · 2013 to 2016
$3.1M
Role of anti-Col (V) immunity in primary graft dysfunctionR01HL096845 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIE, JASON D, WILKES, DAVID S · 2010 to 2013
$2.2M
Mentored Patient Oriented Research in Lung TransplantationK24HL115354 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIE, JASON D · 2012 to 2021
$1.2M
The Role of ABO Glycosyltransferases in the Acute Respiratory Distress SyndromeK23HL125723 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI REILLY, JOHN PATRICK · 2015 to 2019
$840k
Genetic Variation in the ANGPT-TIE Pathway and Risk for Acute Lung InjuryK23HL102254 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MEYER, NUALA JENNINGS · 2010 to 2014
$685k
Acute Adipose Inflammation as a Contributor to Acute Kidney Injury After TraumaK23DK097307 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI SHASHATY, MICHAEL G. S. · 2013 to 2016
$626k
Neuron Specific Enolase and Outcomes in Severe SepsisF32GM116637 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI ANDERSON, BRIAN J. · 2015 to 2015
$64k
NHLBI NIH HHS K23 HL102254NHLBI NIH HHS K23 HL125723NHLBI NIH HHS K23HL125723NHLBI NIH HHS K24 HL115354NHLBI NIH HHS K24HL115354NHLBI NIH HHS R01 HL096845NHLBI NIH HHS R01HL097115NHLBI NIH HHS R01 HL114626NHLBI NIH HHS T32 HL007891NHLBI NIH HHS T32HL007891NIDDK NIH HHS K23 DK097307NIDDK NIH HHS K23DK097307NIGMS NIH HHS F32 GM116637NINDS NIH HHS T32 NS061779
6 · The paper itself

Abstract

backgroundObesity is associated with the development of acute respiratory distress syndrome (ARDS) in at-risk patients. Low plasma levels of adiponectin, a circulating hormone-like molecule, have been implicated as a possible mechanism for this association. The objective of this study was to determine the association of plasma adiponectin level at ICU admission with ARDS and 30-day mortality in patients with severe sepsis and septic shock.

methodsThis is a prospective cohort study of patients admitted to the medical ICU at the Hospital of the University of Pennsylvania. Plasma adiponectin was measured at the time of ICU admission. ARDS was defined by Berlin criteria. Multivariable logistic regression was used to determine the association of plasma adiponectin with the development of ARDS and mortality at 30 days.

resultsThe study included 164 patients. The incidence of ARDS within 5 days of admission was 45%. The median initial plasma adiponectin level was 7.62 mcg/ml (IQR: 3.87, 14.90) in those without ARDS compared to 8.93 mcg/ml (IQR: 4.60, 18.85) in those developing ARDS. The adjusted odds ratio for ARDS associated with each 5 mcg increase in adiponectin was 1.12 (95% CI 1.01, 1.25), p-value 0.025). A total of 82 patients (51%) of the cohort died within 30 days of ICU admission. There was a statistically significant association between adiponectin and mortality in the unadjusted model (OR 1.11, 95% CI 1.00, 1.23, p-value 0.04) that was no longer significant after adjusting for potential confounders.

conclusionsIn this study, low levels of adiponectin were not associated with an increased risk of ARDS in patients with severe sepsis and septic shock. This argues against low levels of adiponectin as a mechanism explaining the association of obesity with ARDS. At present, it is unclear whether circulating adiponectin is involved in the pathogenesis of ARDS or simply represents an epiphenomenon of other unknown functions of adipose tissue or metabolic alterations in sepsis.

Indexed as

AdiponectinAgedCohort StudiesFemaleHumansIntensive Care UnitsLogistic ModelsMaleMiddle AgedObesityPennsylvaniaPrognosisProspective StudiesRespiration, ArtificialRespiratory Distress SyndromeRetrospective StudiesAdiponectinAcute respiratory distress syndromeAdiponectinObesitySepsis

Identifiers

PMID26984771
PMCPMC4794929
OpenAlexW2298970716

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.