Evidence map›Paper›PMID 26984718›Full record

ArticleActa dermato-venereologica2016

Throat Infections are Associated with Exacerbation in a Substantial Proportion of Patients with Chronic Plaque Psoriasis.

Ragna H Thorleifsdottir, Jenna H Eysteinsdóttir, Jón H Olafsson, Martin I Sigurdsson, Andrew Johnston, Helgi Valdimarsson, Bardur Sigurgeirsson

Open access · goldAbstract read
In one paragraph

Article in Acta dermato-venereologica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Antistreptococcal treatment of psoriasis: a systematic review.Archives of dermatological research · 2024
    Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. CD1a and skin T cells: a pathway for therapeutic intervention.Clinical and experimental dermatology · 2024
    Review
  10. Review
  11. Group AScience immunology · 2023
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. The Association Between Oral Health and Skin Disease.The Journal of clinical and aesthetic dermatology · 2020
    Article
  17. Psoriasis and Atopic Dermatitis.Dermatology and therapy · 2017
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ragna H ThorleifsdottirDepartment of Dermatology, Akademiska University Hospital, 75 185 Uppsala, Sweden. ragnahlin@gmail.com.
Jenna H Eysteinsdóttir
Jón H Olafsson
Martin I Sigurdsson
Andrew Johnston
Helgi Valdimarsson
Bardur Sigurgeirsson
University of Iceland · ISNational University Hospital · SG

Funding

Biologic Activities of IL-36 Cytokines in PsoriasisK01AR064765 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHNSTON, ANDREW · 2013 to 2017
$506k
NIAMS NIH HHS K01 AR064765
6 · The paper itself

Abstract

Streptococcal throat infections are known to trigger or exacerbate psoriasis, and several studies support the benefit of tonsillectomy. To evaluate the potential of tonsillectomy as a treatment, we used a retrospective study-specific questionnaire to assess the proportion of psoriasis patients with sore throat-associated psoriasis exacerbations. Our survey sampled 275 psoriasis patients. Of patients with plaque psoriasis, 42% reported sore throat-associated psoriasis exacerbations, and of patients with confirmed streptococcal infections, 72% reported aggravation. Notably, women and patients with early onset psoriasis were more likely to report psoriasis exacerbation after a sore throat (p < 0.001, p = 0.046, respectively). Other psoriasis aggravation factors were more common in patients with sore throat-associated exacerbations (p < 0.01). Of tonsillectomized patients, 49% reported subsequent improvement and had more frequent sore throat-associated aggravation of psoriasis than patients who did not improve after tonsillectomy (p = 0.015). These findings suggest a closer association between sore throats, streptococcal throat infections and plaque psoriasis than reported previously.

Indexed as

AdultFemaleHumansMalePharyngitisPsoriasisRetrospective StudiesStreptococcal InfectionsSurveys and QuestionnairesTonsillectomy

Identifiers

PMID26984718
PMCPMC4995120
OpenAlexW2300195403

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.