ReviewCurrent psychiatry reports2016
Alcohol and Drug Use and the Developing Brain.
Review in Current psychiatry reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
131 citing papers in PubMed, 4 syntheses or guidelines pooled it, 240 citations in OpenAlex.
- The brain in social context: A systematic review of substance use and social processing from adolescence to young adulthood.Developmental cognitive neuroscience · 2022Pooled it
- Clinical and social factors associated with involuntary psychiatric hospitalisation in children and adolescents: a systematic review, meta-analysis, and narrative synthesis.The Lancet. Child & adolescent health · 2021Pooled it
- Electronic nicotine delivery system use is related to higher odds of alcohol and marijuana use in adolescents: Meta-analytic evidence.Addictive behaviors · 2020Pooled it
- Neurobiological and Cognitive Profile of Young Binge Drinkers: a Systematic Review and Meta-Analysis.Neuropsychology review · 2019Pooled it
- How adolescents' working memory abilities relate to their alcohol craving in real-life contexts depends on biological sex.Drug and alcohol dependence · 2021Trial
- Effects of naltrexone are influenced by childhood adversity during negative emotional processing in addiction recovery.Translational psychiatry · 2017Trial
- Alcohol use during a trial of N-acetylcysteine for adolescent marijuana cessation.Addictive behaviors · 2016Trial
- Substance cravings, readiness to change, and perceived social support as determinants of treatment motivation for amphetamine-type stimulant use disorder among youths in malaysian rehabilitation centers.Drug and alcohol dependence reports · 2026Article
- Transcranial Magnetic Stimulation Combined With Electroencephalography Analysis Suggest Time-Dependent and Region-Specific Modulation of Cortical Excitability During Acute Alcohol Intoxication.Alcohol, clinical & experimental research · 2026Article
- Exploring the Relationships Between Social Influence, Vaping Behaviors, and Susceptibility Across Grade Levels in Kentucky.American journal of health promotion : AJHP · 2026Article
- Untangling relationships between cognitive development and child and adolescent mental health: Findings from the ABCD Study.Developmental cognitive neuroscience · 2026Review
- The HOPE program: protocol for a stratified cluster randomized controlled trial to prevent psychoactive substance use and promote health in Moroccan middle school students.Addiction science & clinical practice · 2026Article
- Longitudinal development of the anterior insula-nucleus accumbens white matter pathway through adolescence predicts risk taking in young adulthood.Developmental cognitive neuroscience · 2026Article
- Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth.Molecular psychiatry · 2026Article
- Evaluation of perception towards brain health in Nigeria: Results from a nationwide awareness survey.Journal of public health in Africa · 2026Article
- Prevalence and socio-ecological correlates of adolescent alcohol, tobacco, and marijuana use in the Turks and Caicos Islands.Frontiers in public health · 2026Article
- Multivariable machine learning prediction of risky alcohol use in contemporary youth.Addiction (Abingdon, England) · 2025Article
- The Role of Repetitive Transcranial Magnetic Stimulation in Treating Alcohol Use Disorder: Neural Mechanisms, Efficacy, and Future Directions.Alpha psychiatry · 2025Review
- Contribution of Addictovigilance data to assess adverse-events linked to psychoactive substances in children and adolescents.British journal of clinical pharmacology · 2025Article
- National, regional, and global statistics on alcohol consumption and associated burden of disease 2000-20: a modelling study and comparative risk assessment.The Lancet. Public health · 2025Article
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Adolescence is an important neurodevelopmental period marked by rapidly escalating rates of alcohol and drug use. Over the past decade, research has attempted to disentangle pre- and post-substance use effects on brain development by using sophisticated longitudinal designs. This review focuses on recent, prospective studies and addresses the following important questions: (1) what neuropsychological and neural features predate adolescent substance use, making youth more vulnerable to engage in heavy alcohol or drug use, and (2) how does heavy alcohol and drug use affect normal neural development and cognitive functioning? Findings suggest that pre-existing neural features that relate to increased substance use during adolescence include poorer neuropsychological functioning on tests of inhibition and working memory, smaller gray and white matter volume, changes in white matter integrity, and altered brain activation during inhibition, working memory, reward, and resting state. After substance use is initiated, alcohol and marijuana use are associated with poorer cognitive functioning on tests of verbal memory, visuospatial functioning, psychomotor speed, working memory, attention, cognitive control, and overall IQ. Heavy alcohol use during adolescence is related to accelerated decreases in gray matter and attenuated increases in white matter volume, as well as increased brain activation during tasks of inhibition and working memory, relative to controls. Larger longitudinal studies with more diverse samples are needed to better understand the interactive effects of alcohol, marijuana, and other substances, as well as the role of sex, co-occurring psychopathology, genetics, sleep, and age of initiation on substance use.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.