ArticleCritical care (London, England)2016
The impairment of small nerve fibers in severe sepsis and septic shock.
Article in Critical care (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Associations between ICU survival and self-perceived appetite, smell, and taste relative to general ward patients: A prospective study.JPEN. Journal of parenteral and enteral nutrition · 2026Observational
- The spectrum of sepsis-associated encephalopathy: a clinical perspective.Critical care (London, England) · 2023Review
- Understanding Post-Sepsis Syndrome: How Can Clinicians Help?Infection and drug resistance · 2023Review
- Central and peripheral nervous system complications of COVID-19: a prospective tertiary center cohort with 3-month follow-up.Journal of neurology · 2021Observational
- Muscular weakness and muscle wasting in the critically ill.Journal of cachexia, sarcopenia and muscle · 2020Review
- Sepsis therapies: learning from 30 years of failure of translational research to propose new leads.EMBO molecular medicine · 2020Review
- Skeletal Muscle Index at Intensive Care Unit Admission Is a Predictor of Intensive Care Unit-Acquired Weakness in Patients With Sepsis.Journal of clinical medicine research · 2019Article
- The Influence of Pain and Analgesia in Rodent Models of Sepsis.Comparative medicine · 2019Review
- Chronic pain in critical care survivors: a narrative review.British journal of anaesthesia · 2019Review
- Computed Tomography Evidence of Psoas Muscle Atrophy Without Concomitant Tendon Wasting in Early Sepsis.The Journal of surgical research · 2019Article
- Sepsis-associated encephalopathy.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Article
- Electrophysiologic alterations in the excitability of the sciatic and vagus nerves during early stages of sepsis.Journal of pain research · 2018Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA decrease of small nerve fibers in skin biopsies during the course of critical illness has been demonstrated recently. However, the diagnostic use of skin biopsies in sepsis and its time course is not known.
methodsPatients (n=32) with severe sepsis or septic shock were examined using skin biopsies, neurological examination, nerve conduction studies, and sympathetic skin response in the first week after onset of sepsis, 2 weeks and 4 months later and compared to gender- and age-matched healthy controls.
resultsSkin biopsies at the ankle and thigh revealed a significant decrease of intraepidermal nerve fiber density (IENFD) during the first week of sepsis and 2 weeks later. All patients developed critical illness polyneuropathy (CIP) according to electrophysiological criteria and 11 showed IENFD values lower than the 0.05 quantile. Four patients were biopsied after 4 months and still showed decreased IENFD. Results of nerve conduction studies and IENFD did considerably change over time. No differences for survival time between patients with IEFND lower and larger than 3.5 fibers/mm were found.
conclusionsSkin biopsy is able to detect an impairment of small sensory nerve fibers early in the course of sepsis. However, it may not be suited as a prognostic parameter for survival.
trial registrationGerman Clinical Trials Register, DRKS-ID: DRKS00000642, 12/17/2010.
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