ArticleProceedings. Biological sciences2016
Stickleback embryos use ATP-binding cassette transporters as a buffer against exposure to maternally derived cortisol.
Article in Proceedings. Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Intergenerational plasticity to cycling high temperature and hypoxia affects offspring stress responsiveness and tolerance in zebrafish.The Journal of experimental biology · 2023Article
- Egg-mediated maternal effects in a cooperatively breeding cichlid fish.Scientific reports · 2023Article
- Zebrafish parental progeny investment in response to cycling thermal stress and hypoxia: deposition of heat shock proteins but not cortisol.The Journal of experimental biology · 2022Article
- Optimization of an oral mucosaTissue barriers · 2020Article
- Internal embryonic development in a non-copulatory, egg-laying teleost, the three-spined stickleback, Gasterosteus aculeatus.Scientific reports · 2019Article
- An Integrative Framework for Understanding the Mechanisms and Multigenerational Consequences of Transgenerational Plasticity.Annual review of ecology, evolution, and systematics · 2019Article
- The mineralocorticoid receptor is essential for stress axis regulation in zebrafish larvae.Scientific reports · 2018Article
- Parent-embryo acoustic communication: a specialised heat vocalisation allowing embryonic eavesdropping.Scientific reports · 2018Article
- Integrating Ecological and Evolutionary Context in the Study of Maternal Stress.Integrative and comparative biology · 2017Article
- Maternal cortisol stimulates neurogenesis and affects larval behaviour in zebrafish.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Offspring from females that experience stressful conditions during reproduction often exhibit altered phenotypes and many of these effects are thought to arise owing to increased exposure to maternal glucocorticoids. While embryos of placental vertebrates are known to regulate exposure to maternal glucocorticoids via placental steroid metabolism, much less is known about how and whether egg-laying vertebrates can control their steroid environment during embryonic development. We tested the hypothesis that threespine stickleback (Gasterosteus aculeatus) embryos can regulate exposure to maternal steroids via active efflux of maternal steroids from the egg. Embryos rapidly (within 72 h) cleared intact steroids, but blocking ATP-binding cassette (ABC) transporters inhibited cortisol clearance. Remarkably, this efflux of cortisol was sufficient to prevent a transcriptional response of embryos to exogenous cortisol. Taken together, these findings suggest that, much like their placental counterparts, developing fish embryos can actively regulate their exposure to maternal cortisol. These findings highlight the fact that even in egg-laying vertebrates, the realized exposure to maternal steroids is mediated by both maternal and embryonic processes and this has important implications for understanding how maternal stress influences offspring development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.