ArticleProceedings of the National Academy of Sciences of the United States of America2016
Viral serine palmitoyltransferase induces metabolic switch in sphingolipid biosynthesis and is required for infection of a marine alga.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 64 citations in OpenAlex.
- Marine bacteria degrade viral particles as a source of nitrogen, phosphorus, and sulfur-rich dissolved organic matter.ISME communications · 2026Article
- Phage resistance mutations in a marine bacterium impact biogeochemically relevant cellular processes.Nature microbiology · 2026Article
- Soil viral-host interactions regulate microplastic-dependent carbon storage.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Algal blooms in the ocean: hot spots for chemically mediated microbial interactions.Nature reviews. Microbiology · 2024Review
- Production of structurally diverse sphingolipids by anaerobic marine bacteria in the euxinic Black Sea water column.The ISME journal · 2024Article
- Cell-to-cell heterogeneity drives host-virus coexistence in a bloom-forming alga.The ISME journal · 2024Article
- Virologs, viral mimicry, and virocell metabolism: the expanding scale of cellular functions encoded in the complex genomes of giant viruses.FEMS microbiology reviews · 2023Article
- Identification and Verification of Candidate miRNA Biomarkers with Application to Infection withGenes · 2023Article
- Carbohydrate-Containing Low Molecular Weight Metabolites of Microalgae.Marine drugs · 2023Review
- Lipid biomarkers for algal resistance to viral infection in the ocean.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Functional Profiling and Evolutionary Analysis of a Marine Microalgal Virus Pangenome.Viruses · 2023Article
- Deciphering molecular mechanisms of SARS-CoV-2 pathogenesis and drug repurposing through GRN motifs: a comprehensive systems biology study.3 Biotech · 2023Article
- Viral infection in the ocean-A journey across scales.PLoS biology · 2023Article
- MicroRNA-mediated regulation of lipid metabolism in virus-infected Emiliania huxleyi.The ISME journal · 2022Article
- Review
- Temperate infection in a virus-host system previously known for virulent dynamics.Nature communications · 2020Article
- A single-cell view on alga-virus interactions reveals sequential transcriptional programs and infection states.Science advances · 2020Article
- Metabolic and biogeochemical consequences of viral infection in aquatic ecosystems.Nature reviews. Microbiology · 2020Review
- Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase.Journal of lipid research · 2019Article
- Unmasking cellular response of a bloom-forming alga to viral infection by resolving expression profiles at a single-cell level.PLoS pathogens · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine viruses are the most abundant biological entities in the oceans shaping community structure and nutrient cycling. The interaction between the bloom-forming alga Emiliania huxleyi and its specific large dsDNA virus (EhV) is a major factor determining the fate of carbon in the ocean, thus serving as a key host-pathogen model system. The EhV genome encodes for a set of genes involved in the de novo sphingolipid biosynthesis, not reported in any viral genome to date. We combined detailed lipidomic and biochemical analyses to characterize the functional role of this virus-encoded pathway during lytic viral infection. We identified a major metabolic shift, mediated by differential substrate specificity of virus-encoded serine palmitoyltransferase, a key enzyme of sphingolipid biosynthesis. Consequently, unique viral glycosphingolipids, composed of unusual hydroxylated C17 sphingoid bases (t17:0) were highly enriched in the infected cells, and their synthesis was found to be essential for viral assembly. These findings uncover the biochemical bases of the virus-induced metabolic rewiring of the host sphingolipid biosynthesis during the chemical "arms race" in the ocean.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.