Evidence map›Paper›PMID 26984347›Full record

ArticleLasers in medical science2016

808-nm laser therapy with a flat-top handpiece photobiomodulates mitochondria activities of Paramecium primaurelia (Protozoa).

Andrea Amaroli, Silvia Ravera, Steven Parker, Isabella Panfoli, Alberico Benedicenti, Stefano Benedicenti

Abstract read
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Article in Lasers in medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

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  8. Near-Infrared 810 nm Light Affects PoriferaInternational journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Andrea AmaroliDepartment of Earth, Environmental and Life Sciences, Protistology Laboratory, University of Genoa, Corso Europa, 26, 16132, Genoa, Italy.
Silvia RaveraDepartment of Pharmacy, Biochemistry Laboratory, University of Genoa, Viale Benedetto XV, 3, 16132, Genoa, Italy.
Steven ParkerDepartment of Surgical Sciences and Integrated Diagnostic, University of Genoa, Largo R. Benzi, 10, 16132, Genoa, Italy.
Isabella PanfoliDepartment of Pharmacy, Biochemistry Laboratory, University of Genoa, Viale Benedetto XV, 3, 16132, Genoa, Italy.
Alberico BenedicentiDepartment of Surgical Sciences and Integrated Diagnostic, University of Genoa, Largo R. Benzi, 10, 16132, Genoa, Italy.
Stefano BenedicentiDepartment of Surgical Sciences and Integrated Diagnostic, University of Genoa, Largo R. Benzi, 10, 16132, Genoa, Italy. stefano.benedicenti@tiscali.it.
University of Genoa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photobiomodulation is proposed as a non-linear process, and only low-level laser therapy (LLLT) is assumed to stimulate exposed cells, whereas high powered laser and fluences can cause negative effects, exhausting the cell's energy reserve as a consequence of excessive photon-based stimulation. In our work, we investigated and compared the effects of 808-nm diode laser (CW) with a new flat-top handpiece. To this purpose, we tested the photobiomodulation effects of 1 and 3 J/cm(2) fluence, both generated by 100 mW or 1 W of laser power and of 64 J/cm(2) of fluence generated by 100 mW, 1 W, 1.5 W or 2 W, as expressed through oxygen consumption and ATP synthesis of Paramecium. Data collected indicates the incremental consumption of oxygen through irradiation with 3 J/cm(2)-100 mW or 64 J/cm(2)-1 W correlates with an increase in Paramecium ATP synthesis. The Paramecium respiration was inhibited by fluences 64 J/cm(2)-100 mW or 64 J/cm(2)-2 W and was followed by a decrease in the endogenous ATP concentration. The 1 J/cm(2)-100 mW or 1 W and 3 J/cm(2)-1 W did not affect mitochondrial activity. The results show that the fluence of 64 J/cm(2)-1 W more than the 3 J/cm(2)-100 mW causes greater efficiency in Paramecium mitochondria respiratory chain activity. Our results suggest that thanks to flat-top handpiece we used, high fluences by high-powered laser have to be reconsidered as an effective and non-invasive therapy. Possible associated benefits of deeper tissue penetration would increase treatment effectiveness and reduced irradiation time.

Indexed as

Lasers, SemiconductorAdenosine TriphosphateHumansMitochondriaOxygen ConsumptionParameciumAdenosine TriphosphateHigh fluenceLaser irradiationLaser phototherapyLow-level laser therapyMitochondriaPhotobiostimulation

Identifiers

PMID26984347
OpenAlexW2301083995

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.