Evidence map›Paper›PMID 26984291›Full record

ArticleSexual medicine2016

Intralesional Injection of Hyaluronic Acid in Patients Affected With Peyronie's Disease: Preliminary Results From a Prospective, Multicenter, Pilot Study.

Alessandro Zucchi, Elisabetta Costantini, Tommaso Cai, Giorgio Cavallini, Giovanni Liguori, Vincenzo Favilla, Gaetano De Grande, Giuseppe D'Achille, Mauro Silvani, Giorgio Franco and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sexual medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

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  19. Comparison of Intralesional Hyaluronic AcidThe world journal of men's health · 2021
    Article
  20. Peyronie's disease - outcomes of collagenaseArab journal of urology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 12 institutions in 2 countries.

Alessandro ZucchiUrology and Andrology Department, University of Perugia, Perugia, Italy.
Elisabetta CostantiniUrology and Andrology Department, University of Perugia, Perugia, Italy.
Tommaso CaiUrology Unit, Santa Chiara Regional Hospital, Trento, Italy.
Giorgio CavalliniMedicitalia Andrology Section, Outpatient Clinic of Ferrara, Ferrara, Italy.
Giovanni LiguoriUrology Unit, Cattinara Hospital, Trieste, Italy.
Vincenzo FavillaUrology Department, University of Catania, Catania, Italy.
Gaetano De GrandeUrology Unit, Umberto I Hospital, Siracusa, Italy.
Giuseppe D'AchilleUrology Unit, San Giacomo Hospital, Monopoli, Italy.
Mauro SilvaniUrology Unit, "degli Infermi" Hospital, Biella, Italy.
Giorgio FrancoUrology Department, University "La Sapienza", Rome, Italy.
Alessandro PalmieriUrology Department, University of Naples Federico II, Naples, Italy.
Paolo VerzeUrology Department, University of Naples Federico II, Naples, Italy. Electronic address: pverze@gmail.com.
Vincenzo MironeUrology Department, University of Naples Federico II, Naples, Italy.
University of Perugia · ITIter · ITNaples Anesthesia & Physician Associates · USOspedale degli Infermi · ITOspedale San Giacomo Apostolo · ITOspedale Santa Chiara · ITOspedali Riuniti Umberto I · ITSapienza University of Rome · ITUniversity of Catania · ITUniversity of Ferrara · ITUniversity of Naples Federico II · ITUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHyaluronic acid has been shown to be efficacious in decreasing scar formation, inflammation, and oxidative stress.

aimTo assess the efficacy of intralesional injection of hyaluronic acid in patients affected by Peyronie's disease.

methodsIn this prospective, single-arm, self-controlled, interventional, multicenter pilot study, 65 patients underwent a 10-week cycle of weekly intraplaque injections with hyaluronic acid (0.8% highly purified sodium salt hyaluronic acid 16 mg/2 mL; Sinovial, IBSA, Lodi, Italy). Patients were re-evaluated 2 months after the end of therapy.

main outcome measuresPlaque size (millimeters), penile curvature (degrees), International Index of Erectile Function (IIEF-5) score, visual analog scale (VAS) score for sexual satisfaction, and Patient's Global Impressions of Improvement (PGI-I) score.

resultsMedian age was 57 years (range = 23-70). At baseline, mean plaque size was 10 mm (range = 3-30 mm), mean penile curvature was 30° (range = 0°-50°), and mean IIEF-5 score was 20 (range = 0-25), with slight to moderate erectile dysfunction (IIEF score < 21) in 36 of 65 patients (55%). A median VAS score of 6 (range = 2-10) was found. Mean follow-up was 12 months (range = 6-24 months). Statistically significant post-treatment improvements were detected for plaque size (before treatment = 10 mm [3-30 mm], after treatment = 8 mm [1-30 mm], P < .0001), penile curvature (before treatment = 30° [0°-50°], after treatment = 20° [0°-40°], P < .0001), IIEF-5 score (before treatment = 20 [11-25], after treatment = 21 [15-25], P < .0001), and VAS score (before treatment = 6 [2-10], after treatment 8 [2-10], P < .0001). After treatment, the rate of patients with an IIEF score lower than 21 decreased from 55% (36 patients) to 40% (25 patients). Overall improvement on the PGI-I questionnaire was 69%.

conclusionIntralesional treatment with hyaluronic acid can improve plaque size, penile curvature, and overall sexual satisfaction and seems preferably indicated in the early (active) phase of the disease. Furthermore, it is easy to perform and well tolerated.

Indexed as

Hyaluronic AcidIntralesional TherapyPenile CurvaturePeyronie's Disease

Identifiers

PMID26984291
PMCPMC5005307
OpenAlexW2301127695

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.