Evidence map›Paper›PMID 26984232›Full record

ArticleJournal of assisted reproduction and genetics2016

Vitrification of in vitro matured oocytes collected from surplus ovarian medulla tissue resulting from fertility preservation of ovarian cortex tissue.

Huiqun Yin, Hong Jiang, Stine Gry Kristensen, Claus Yding Andersen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. New Insights on In Vitro Maturation of Oocytes for Fertility Preservation.International journal of molecular sciences · 2024
    Review
  5. Mature oocyte found during ovarian tissue cryopreservation in an early adolescent female.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024
    Article
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  7. Moving the context of preserving fertility into an expanded domain.Journal of assisted reproduction and genetics · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Huiqun YinReproductive Medicine Center, 105th Hospital of PLA, Hefei, China.
Hong JiangReproductive Medicine Center, 105th Hospital of PLA, Hefei, China.
Stine Gry KristensenLaboratory of Reproductive Biology, University Hospital of Copenhagen, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Claus Yding AndersenLaboratory of Reproductive Biology, University Hospital of Copenhagen, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark. yding@rh.dk.
University of Copenhagen · DK82th Hospital of Pla · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of the study was to investigate the maturation rate of immature oocytes collected from ovarian medulla tissue normally discarded during preparation of ovarian cortical tissue for fertility preservation. Further we evaluated survival of derived MII oocytes following vitrification and warming.

methods36 patients aged from 8 to 41 years who had one ovary excised for fertility preservation were included. Oocytes were collected from the medulla tissue and matured in vitro 44-48 h followed by vitrification. Number of oocytes collected, the rates of maturation and post-warming survival were assessed.

resultsOn average, 11 immature oocytes were collected per patient. The overall maturation rate was 29 % irrespective of whether the ovary was transported 4-5 h on ice or obtained immediately after oophorectomy. The maturation rate in patients below 20 years of age (55 %) was significantly higher than that of patients aged 20-30 years (29 %) and above 30 years (26 %). The post-warming survival rate was 64 %. No significant relationship was observed between the number of collected oocytes and the age of patients.

conclusionsApproximately three MII oocytes were obtained per patient following in vitro maturation (IVM) of immature oocytes collected from medulla tissue, of which two survived vitrification and warming. This approach represents an add-on method to potentially augment the fertility opportunity for cancer patients, especially in young women with cancer where transplantation of cortical tissue may pose a risk of relapse, but the IVM approach is currently too inefficient to be the only method used for fertility preservation.

Indexed as

VitrificationAdolescentAdultChildCryopreservationFemaleFertility PreservationHumansIn Vitro Oocyte Maturation TechniquesOocyte RetrievalOocytesOvariectomyFertility preservationIn vitro maturationOocyteOvarian cortex cryopreservationVitrification

Identifiers

PMID26984232
PMCPMC4889476
OpenAlexW2310921738

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.