Evidence map›Paper›PMID 26984114›Full record

ArticleNeuromolecular medicine2016

Biomarkers of Resilience in Stress Reduction for Caregivers of Alzheimer's Patients.

Lap Ho, Patricia A Bloom, Joan G Vega, Shrishailam Yemul, Wei Zhao, Libby Ward, Evan Savage, Robert Rooney, Divyen H Patel, Giulio Maria Pasinetti

Abstract read
PubMed Publisher
In one paragraph

Article in Neuromolecular medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lap HoDepartment of Neurology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, Annenberg Building, Room 20-02, New York, NY, 10029, USA.
Patricia A BloomDepartment of Geriatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Joan G VegaDepartment of Geriatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Shrishailam YemulDepartment of Neurology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, Annenberg Building, Room 20-02, New York, NY, 10029, USA.
Wei ZhaoDepartment of Neurology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, Annenberg Building, Room 20-02, New York, NY, 10029, USA.
Libby WardDepartment of Neurology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, Annenberg Building, Room 20-02, New York, NY, 10029, USA.
Evan SavageGenome Explorations, Inc., Memphis, TN, 38105, USA.
Robert RooneyGenome Explorations, Inc., Memphis, TN, 38105, USA.
Divyen H PatelGenome Explorations, Inc., Memphis, TN, 38105, USA.
Giulio Maria PasinettiDepartment of Neurology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, Annenberg Building, Room 20-02, New York, NY, 10029, USA. Giulio.Pasinetti@mssm.edu.
Icahn School of Medicine at Mount Sinai · USUniversity of Memphis · USHuman Genome Sciences (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Caregiving for a dementia patient is associated with increased risk of psychological and physical health problems. We investigated whether a mindfulness-based stress reduction (MBSR) training course for caregivers that closely models the MBSR curriculum originally established by the Center of Mindfulness at the University of Massachusetts may improve the psychological resilience of non-professional caregivers of Alzheimer's disease patients. Twenty adult non-professional caregivers of dementia patients participated in an 8-week MBSR training course. Caregiver stress, depression, burden, grief, and gene expression profiles of blood mononuclear cells were assessed at baseline and following MBSR. MBSR training significantly improved the psychological resilience of some of the caregivers. We identified predictive biomarkers whose expression is associated with the likelihood of caregivers to benefit from MBSR, and biomarkers whose expression is associated with MBSR psychological benefits. Our biomarker studies provide insight into the mechanisms of health benefits of MBSR and a basis for developing a personalized medicine approach for applying MBSR for promoting psychological and cognitive resilience in caregivers of dementia patients.

Indexed as

MindfulnessBiomarkersCaregiversGene Expression RegulationHumansStress, PsychologicalTranscriptomeBiomarkersDementiaDepressionEmotional distressFamily caregiverMindfulness-based stress reduction

Identifiers

PMID26984114
OpenAlexW2321883894

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.