ArticleVeterinary research2016
Experimental ovine toxoplasmosis: influence of the gestational stage on the clinical course, lesion development and parasite distribution.
Article in Veterinary research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Fetal and neonatal demise in zoonotic diseases: pathology and pathogenesis.Infection and immunity · 2026Review
- Vaccination with live-attenuated Toxoplasma gondii mutants RHΔtkl1 and PruΔpp2a-c induces protective immunity in sheep.Parasites & vectors · 2026Article
- A safe and efficacious inactivated vaccine aids prevent reproductive failure associated with congenital toxoplasmosis in ovine.Veterinary research · 2026Article
- BKI-1748 confers a high level of protection against ovine congenital toxoplasmosis when administered after IgM seroconversion.Frontiers in cellular and infection microbiology · 2026Article
- Longitudinal study of antibody kinetics and vertical transmission of Toxoplasma gondii in naturally infected pregnant sheep in Brazil.Tropical animal health and production · 2025Article
- Early dynamics of Toxoplasma gondii infection in sheep inoculated at mid-gestation with archetypal type II oocysts.Veterinary research · 2025Article
- Treatment with BKI-1748 afterAntimicrobial agents and chemotherapy · 2025Article
- Genetic diversity ofCurrent research in parasitology & vector-borne diseases · 2024Article
- Toxoplasma gondii is not an important contributor to poor reproductive performance of primiparous ewes from southern Australia: a prospective cohort study.BMC veterinary research · 2022Article
- Advances in vaccine development and the immune response against toxoplasmosis in sheep and goats.Frontiers in veterinary science · 2022Review
- Unifying Virulence Evaluation inFrontiers in cellular and infection microbiology · 2022Review
- In vivo and in vitro models show unexpected degrees of virulence among Toxoplasma gondii type II and III isolates from sheep.Veterinary research · 2021Article
- Toxoplasma Effectors that Affect Pregnancy Outcome.Trends in parasitology · 2021Review
- Toll-Like Receptor 2 is Involved in Abnormal Pregnancy in Mice Infected withFrontiers in microbiology · 2021Article
- Modeling the Ruminant Placenta-Pathogen Interactions in Apicomplexan Parasites: Current and Future Perspectives.Frontiers in veterinary science · 2020Review
- Isolation, Genotyping, and Mouse Virulence Characterization ofFrontiers in veterinary science · 2020Article
- Effective Nanoparticle-Based Nasal Vaccine Against Latent and Congenital Toxoplasmosis in Sheep.Frontiers in immunology · 2020Article
- Peripheral and placental immune responses in sheep after experimental infection with Toxoplasma gondii at the three terms of gestation.Veterinary research · 2019Article
- Treatment with Bumped Kinase Inhibitor 1294 Is Safe and Leads to Significant Protection against Abortion and Vertical Transmission in Sheep Experimentally Infected with Toxoplasma gondii during Pregnancy.Antimicrobial agents and chemotherapy · 2019Article
- Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relation between gestational age and foetal death risk in ovine toxoplasmosis is already known, but the mechanisms involved are not yet clear. In order to study how the stage of gestation influences these mechanisms, pregnant sheep of the same age and genetic background were orally dosed with 50 oocysts of Toxoplasma gondii (M4 isolate) at days 40 (G1), 90 (G2) and 120 (G3) of gestation. In each group, four animals were culled on the second, third and fourth week post infection (pi) in order to evaluate parasite load and distribution, and lesions in target organs. Ewes from G1 showed a longer period of hyperthermia than the other groups. Abortions occurred in all groups. While in G2 they were more frequent during the acute phase of the disease, in G3 they mainly occurred after day 20 pi. After challenge, parasite and lesions in the placentas and foetuses were detected from day 19 pi in G3 while in G2 or G1 they were only detected at day 26 pi. However, after initial detection at day 19 pi, parasite burden, measured through RT-PCR, in placenta or foetus of G3 did not increase significantly and, at in the third week pi it was lower than that measured in foetal liver or placenta from G1 to G3 respectively. These results show that the period of gestation clearly influences the parasite multiplication and development of lesions in the placenta and foetus and, as a consequence, the clinical course in ovine toxoplasmosis.
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