Observational studyScandinavian journal of trauma, resuscitation and emergency medicine2016
Traumatic brain injury is not associated with significant myocardial dysfunction: an observational pilot study.
Observational study in Scandinavian journal of trauma, resuscitation and emergency medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Cardiac Dysfunction in Blunt Traumatic Brain Injury Patients.Critical care explorations · 2026Article
- Hemodynamic characterization of cardiac dysfunction after traumatic brain injury using a controlled cortical impact model in male rats.Physiological reports · 2026Article
- Carbon monoxide-releasing molecule-3 ameliorates traumatic brain injury-induced cardiac dysfunctions via inhibition of pyroptosis and apoptosis.Molecular and cellular biochemistry · 2025Article
- Traumatic brain injury and risk of heart failure and coronary heart disease: A nationwide population-based cohort study.PloS one · 2023Article
- A prospective exploratory study to assess echocardiographic changes in patients with supratentorial tumors - Effect of craniotomy and tumor decompression.Surgical neurology international · 2023Article
- Targeting hydrogen sulfide and nitric oxide to repair cardiovascular injury after trauma.Nitric oxide : biology and chemistry · 2022Review
- Case Report: Takotsubo Cardiomyopathy After Traumatic Brain Injury.Frontiers in neurology · 2021Article
- The Short-Term Effects of Isolated Traumatic Brain Injury on the Heart in Experimental Healthy Rats.Neurocritical care · 2020Article
- Significance of Cardiac Troponin I Elevation in Traumatic Brain Injury Patients.Anesthesiology and pain medicine · 2019Article
- Cardiac Dysfunction in Adult Patients with Traumatic Brain Injury: A Prospective Cohort Study.Clinical medicine & research · 2018Observational
- Early Systolic Dysfunction Following Traumatic Brain Injury: A Cohort Study.Critical care medicine · 2017Article
- Incidence and outcome of cardiac injury in patients with severe head trauma.Scandinavian journal of trauma, resuscitation and emergency medicine · 2016Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMyocardial dysfunction has been well described with catastrophic neurological events, such as subarachnoid hemorrhage and brain death. There is very limited data describing myocardial function in the context of traumatic brain injury (TBI), as no prospective study has yet examined this association. The objective of our study was to evaluate cardiac function using echocardiography in patients with clinically important TBI.
methodsWe conducted a prospective observational study of consecutive TBI patients admitted to the intensive care unit. All patients older than 16 years with moderate to severe TBI according to the Glascow Coma Scale (GCS) were eligible for the study. Only patients with a prior history of heart disease or cardiomyopathy or evidence of brain death on admission were excluded. A complete transthoracic echocardiogram was performed within 4 days of admission.
resultsForty-nine patients (67% males, median age 34 years) were included in the study. Forty-one patients had severe TBI (84%) with a median GCS of six, 44 patients (90%) required mechanical ventilation and 36 (74%) intracranial pressure monitoring. Hospital mortality was 18%. No patients had global left ventricular dysfunction as defined by a left ventricular ejection fraction (LVEF) below 50% (95% CI, 0-0.07). Average LVEF was 65 +/- 4%. Four patients (8%) had regional wall motion abnormalities with preserved LVEF. DISCUSSION: The main finding of this study is the absence of clinically significant myocardial dysfunction in patients with moderate or severe TBI. Although myocardial dysfunction has been well described in a variety of neurological settings, it is possible that the young age of TBI patients and the absence of cardiovascular risk factors are protective against significant myocardial injury from catecholamine excess.
conclusionsIn a group of patients with clinically important TBI, we did not identify any significant cardiac dysfunction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.