ArticleSurgery today2016
A non-smooth tumor margin on preoperative imaging predicts microvascular invasion of hepatocellular carcinoma.
Article in Surgery today, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Quality of radiomics for predicting microvascular invasion in hepatocellular carcinoma: a systematic review.European radiology · 2023Pooled it
- Diagnostic value of magnetic resonance imaging features of microvascular invasion in hepatocellular carcinoma: a meta-analysis.Diagnostic and interventional radiology (Ankara, Turkey) · 2022Pooled it
- A non-smooth tumor margin on preoperative imaging assesses microvascular invasion of hepatocellular carcinoma: A systematic review and meta-analysis.Scientific reports · 2017Pooled it
- Using pre-operative radiomics to predict microvascular invasion of hepatocellular carcinoma based on Gd-EOB-DTPA enhanced MRI.BMC medical imaging · 2022Trial
- Predictive value of a constructed artificial neural network model for microvascular invasion in hepatocellular carcinoma: A retrospective study.World journal of gastrointestinal oncology · 2025Article
- Development of a Novel Comprehensive Hepatocellular Carcinoma Outcome Prognostic Scoring System With Integration of Imaging Features.The oncologist · 2024Article
- Machine learning based ultrasomics noninvasive predicting EGFR expression status in hepatocellular carcinoma patients.Frontiers in medicine · 2024Article
- Radiomics nomogram for the prediction of microvascular invasion of HCC and patients' benefit from postoperative adjuvant TACE: a multi-center study.European radiology · 2023Article
- Preoperative determination of pathological grades of primary single HCC: development and validation of a scoring model.Abdominal radiology (New York) · 2022Article
- Prediction of microvascular invasion in HCC by a scoring model combining Gd-EOB-DTPA MRI and biochemical indicators.European radiology · 2022Article
- Radiomics nomogram for prediction of microvascular invasion in hepatocellular carcinoma based on MR imaging with Gd-EOB-DTPA.Frontiers in oncology · 2022Article
- Value of gadoxetic acid-enhanced MRI for microvascular invasion of small hepatocellular carcinoma: a retrospective study.BMC medical imaging · 2021Article
- Prediction of Microvascular Invasion and Its M2 Classification in Hepatocellular Carcinoma Based on Nomogram Analyses.Frontiers in oncology · 2021Article
- Prediction of HCC microvascular invasion with gadobenate-enhanced MRI: correlation with pathology.European radiology · 2020Article
- Ultrasound-based radiomics score: a potential biomarker for the prediction of microvascular invasion in hepatocellular carcinoma.European radiology · 2019Article
- Prognostic value of preoperative computed tomography in HBV-related hepatocellular carcinoma patients after curative resection.OncoTargets and therapy · 2019Article
- Preoperative prediction of microvascular invasion of hepatocellular carcinoma usingEuropean journal of nuclear medicine and molecular imaging · 2018Article
- The prognostic value of microvascular invasion in early-intermediate stage hepatocelluar carcinoma: a propensity score matching analysis.BMC cancer · 2018Article
- Need for normalization: the non-standard reference standard for microvascular invasion diagnosis in hepatocellular carcinoma.World journal of surgical oncology · 2018Review
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13 authors.
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Abstract
purposesMicrovascular invasion (mVI) is known to be a risk factor of hepatocellular carcinoma (HCC) recurrence. Several factors such as the tumor grade, tumor size, tumor margin status on imaging studies, fluorine-18 fluorodeoxyglucose-positron emission tomography ((18)F-FDG-PET) results, and tumor markers have been proposed to predict mVI of HCC. However, the values of these factors have not yet been validated.
methodsAmong the patients evaluated using enhanced CT/MRI, (18)F-FDG-PET, and tumor markers prior to hepatectomy from 2007 to 2012, 79 HCC patients without apparent macrovascular invasion in preoperative imaging were enrolled in this study. The image tumor margin status (smooth/non-smooth), (18)F-FDG-PET, and tumor markers, which were previously described as predictors for mVI, were evaluated.
resultsFifteen patients had mVI (mVI+ group) and 64 patients had no evidence of mVI (mVI- group) on pathological examinations. A univariate analysis showed that the mVI+ group had a higher SUV and TNR (5.2 vs 3.8, p = 0.02 and 1.8 vs 1.3, p = 0.02, respectively) and a higher portion of non-smooth tumor margin (87 vs 27 %, p = 0.0001). There was no significant difference in the tumor markers. A multivariate analysis showed that non-smooth tumor margin alone could independently predict mVI (odds ratio 18.3, 95 % CI 3.27-102.6, p = 0.0009).
conclusionA non-smooth tumor margin on preoperative imaging predicts microvascular invasion of HCC.
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