Evidence map›Paper›PMID 26983640›Full record

ArticleBMC medical research methodology2016

Comparing survival curves based on medians.

Zhongxue Chen, Guoyi Zhang

Abstract readComparative Study
In one paragraph

Article in BMC medical research methodology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zhongxue ChenDepartment of Epidemiology and Biostatistics, School of Public Health, Indiana University Bloomington, 1025 E. 7th street, SPH C104, Bloomington, IN, 47405, USA. zc3@indiana.edu.
Guoyi ZhangDepartment of Mathematics and Statistics, University of New Mexico, Albuquerque, NM, 87131, USA.

Funding

Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
NCATS NIH HHS UL1 TR001108
6 · The paper itself

Abstract

backgroundAlthough some nonparametric methods have been proposed in the literature to test for the equality of median survival times for censored data in medical research, in general they have inflated type I error rates, which make their use limited in practice, especially when the sample sizes are small.

methodsIn this paper, we propose a new nonparametric test with a simple test statistic to compare median survival times.

resultsThe results from our comprehensive simulation study show the new test controls type I error rate very well under all situations considered, even for small sample sizes. In addition, it has comparable detecting power compared to existing methods. Another advantage of the proposed test is its relatively simple formula that requires less computation.

conclusionsWe propose a new statistical method for comparing survival curves based on their medians. The new method can be easily implemented and applied to censored event time data.

Indexed as

Kaplan-Meier EstimateModels, StatisticalBiometryComputer SimulationFemaleHumansMaleSample SizeSensitivity and SpecificitySurvival AnalysisTime FactorsCensored dataCochran testNonparametric testSurvival analysis

Identifiers

PMID26983640
PMCPMC4793497

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.