ArticleAnais brasileiros de dermatologia
Correlation of serum IgE levels and clinical manifestations in patients with actinic prurigo.
Article in Anais brasileiros de dermatologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 22 citations in OpenAlex.
- Treatments for actinic prurigo: A case report with upadacitinib and systematic review.SAGE open medical case reports · 2026Article
- Refractory pediatric actinic prurigo successfully treated with upadacitinib: A case report.SAGE open medical case reports · 2025Article
- The Immunogenetics of Photodermatoses.Advances in experimental medicine and biology · 2022Article
- Risk factors associated with actinic prurigo: a case control study.Anais brasileiros de dermatologiaArticle
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundActinic prurigo is an idiopathic photodermatosis, the pathophysiology of which has been hypothesized to involve subtype IV type b (Th2) hypersensitive response, whereby IL4, IL5, and IL13 are secreted and mediate the production of B cells, IgE, and IgG4.
objectivesTo examine the association of serum IgE levels and the clinical severity of injuries.
methodsThis case-control study comprised patients with a clinical and histopathological diagnosis of actinic prurigo, as well as clinically healthy subjects, from whom 3cc of peripheral blood was taken for immunoassay. Cases were classified by lesion severity as mild, moderate, and severe. Descriptive statistics were analyzed, and chi-square test was performed.
resultsWe included 21 actinic prurigo patients and 21 subjects without disease; 11 patients with actinic prurigo had elevated serum IgE levels, and 10 had low serum levels. Six actinic prurigo (AP) patients with elevated serum levels of IgE had moderate injuries, 4 had severe injuries, and 1 had minor injuries. Eight out of 10 patients with normal IgE levels presented with minor injuries in the clinical evaluation. The 21 controls did not have increased serum IgE levels.
conclusionsElevated IgE levels are associated with moderate to severe clinical lesions, suggesting that actinic prurigo entails a type IV subtype b hypersensitivity response in which Th2 cells predominate.
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