Evidence map›Paper›PMID 26982729›Full record

ArticleNature2016

Lytic to temperate switching of viral communities.

B Knowles, C B Silveira, B A Bailey, K Barott, V A Cantu, A G Cobián-Güemes, F H Coutinho, E A Dinsdale, B Felts, K A Furby and 33 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 326 papers.

0numbers the graph read from it
0cells of the map it votes in
326citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

326 citing papers in PubMed.

  1. Article
  2. Article
  3. Temperate phages limit their own propagation under spatial constraint in biofilms on chitin.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Alternating High-Fat and Polysaccharide Diets Modulates Gut Phage-Bacterial Interplay.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

266 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

43 authors.

B KnowlesDepartment of Biology, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
C B SilveiraDepartment of Biology, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
B A BaileyDepartment of Mathematics and Statistics, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
K BarottHawaii Institute of Marine Biology, University of Hawaii at Manoa, 46-007 Lilipuna Road, Kaneohe, Hawaii 96744, USA.
V A CantuComputational Science Research Center, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
A G Cobián-GüemesDepartment of Biology, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
F H CoutinhoBiology Institute, Rio de Janeiro Federal University, Av. Carlos Chagas Filho 373, Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.
E A DinsdaleDepartment of Biology, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
B FeltsDepartment of Mathematics and Statistics, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
K A FurbyRadboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Centre for Molecular and Biomolecular Informatics, 6525HP Nijmegen, The Netherlands.
E E GeorgeDepartment of Biology, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
K T GreenDepartment of Biology, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
G B GregoracciViral Information Institute, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
A F HaasDepartment of Biology, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
J M HaggertyDepartment of Biology, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
E R HesterDepartment of Biology, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
N HisakawaDepartment of Biology, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
L W KellyDepartment of Biology, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
Y W LimDepartment of Biology, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
M LittleDepartment of Biology, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
A LuqueDepartment of Mathematics and Statistics, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
T McDole-SomeraRadboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Centre for Molecular and Biomolecular Informatics, 6525HP Nijmegen, The Netherlands.
K McNairComputational Science Research Center, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
L S de OliveiraBiology Institute, Rio de Janeiro Federal University, Av. Carlos Chagas Filho 373, Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.
S D QuistadDepartment of Biology, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
N L RobinettDepartment of Biology, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
E SalaScripps Institution of Oceanography, 8622 Kennel Way, La Jolla, California 92037, USA.
P SalamonDepartment of Mathematics and Statistics, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
S E SanchezDepartment of Biology, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
S SandinRadboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Centre for Molecular and Biomolecular Informatics, 6525HP Nijmegen, The Netherlands.
G G Z SilvaComputational Science Research Center, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
J SmithRadboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Centre for Molecular and Biomolecular Informatics, 6525HP Nijmegen, The Netherlands.
C SullivanMarine Sciences Department, Sao Paulo Federal University - Baixada Santista, Av. Alm. Saldanha da Gama, 89, Santos, São Paulo 11030-400, Brazil.
C ThompsonBiology Institute, Rio de Janeiro Federal University, Av. Carlos Chagas Filho 373, Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.
M J A VermeijNational Geographic Society, 1145 17th St NW, Washington D.C. 20036, USA.
M YouleCARMABI Foundation, Piscaderabaai z/n, Willemstad, Curacao, Netherlands Antilles.
C YoungAquatic Microbiology, Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, 1098XH Amsterdam, The Netherlands.
B ZgliczynskiRadboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Centre for Molecular and Biomolecular Informatics, 6525HP Nijmegen, The Netherlands.
R BrainardAquatic Microbiology, Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, 1098XH Amsterdam, The Netherlands.
R A EdwardsComputational Science Research Center, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
J NultonDepartment of Mathematics and Statistics, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
F ThompsonBiology Institute, Rio de Janeiro Federal University, Av. Carlos Chagas Filho 373, Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.
F RohwerDepartment of Biology, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbial viruses can control host abundances via density-dependent lytic predator-prey dynamics. Less clear is how temperate viruses, which coexist and replicate with their host, influence microbial communities. Here we show that virus-like particles are relatively less abundant at high host densities. This suggests suppressed lysis where established models predict lytic dynamics are favoured. Meta-analysis of published viral and microbial densities showed that this trend was widespread in diverse ecosystems ranging from soil to freshwater to human lungs. Experimental manipulations showed viral densities more consistent with temperate than lytic life cycles at increasing microbial abundance. An analysis of 24 coral reef viromes showed a relative increase in the abundance of hallmark genes encoded by temperate viruses with increased microbial abundance. Based on these four lines of evidence, we propose the Piggyback-the-Winner model wherein temperate dynamics become increasingly important in ecosystems with high microbial densities; thus 'more microbes, fewer viruses'.

Indexed as

EcosystemHost-Pathogen InteractionsAnimalsAnthozoaBacteriophagesCoral ReefsGenes, ViralLysogenyModels, BiologicalVirulenceViruses

Identifiers

PMID26982729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.