ArticleEmerging infectious diseases2016
Quantifying Transmission of Clostridium difficile within and outside Healthcare Settings.
Article in Emerging infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Interventions to improve appropriate antibiotic prescribing in long-term care facilities: a systematic review.BMC geriatrics · 2020Pooled it
- Investigating in-hospital transmission ofJournal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2025Article
- The contribution of community transmission to the burden of hospital-associated pathogens: A systematic scoping review of epidemiological models.One health (Amsterdam, Netherlands) · 2025Review
- Identifying Contact Time Required for Secondary Transmission of Clostridioides difficile Infections by Using Real-Time Locating System.Emerging infectious diseases · 2024Article
- Diagnostic stewardship to improve patient outcomes and healthcare-associated infection (HAI) metrics.Infection control and hospital epidemiology · 2024Article
- Genomic surveillance ofmBio · 2024Article
- Development of a Prediction Model to Identify the Risk ofPharmacy (Basel, Switzerland) · 2024Article
- Article
- Genomic epidemiology and transmission dynamics of recurrent Clostridioides difficile infection in Western Australia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Article
- A review of epidemiological models of Clostridioides difficile transmission and control (2009-2021).Anaerobe · 2022Review
- Clostridium Difficile and COVID-19: General Data, Ribotype, Clinical Form, Treatment-Our Experience from the Largest Infectious Diseases Hospital in Western Romania.Medicina (Kaunas, Lithuania) · 2021Observational
- Article
- Transmission Dynamics of Clostridioides difficile in 2 High-Acuity Hospital Units.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Epidemiology of community-acquired and recurrentTherapeutic advances in gastroenterology · 2021Review
- Fecal Microbiota Transplants Annually and Their Positive Clinical Impact.Clinical and translational gastroenterology · 2020Article
- Article
- The Clinical Burden ofOpen forum infectious diseases · 2020Article
- Article
- Modelling microbial infection to address global health challenges.Nature microbiology · 2019Review
- Whole-genome sequencing reveals nosocomial Clostridioides difficile transmission and a previously unsuspected epidemic scenario.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
To quantify the effect of hospital and community-based transmission and control measures on Clostridium difficile infection (CDI), we constructed a transmission model within and between hospital, community, and long-term care-facility settings. By parameterizing the model from national databases and calibrating it to C. difficile prevalence and CDI incidence, we found that hospitalized patients with CDI transmit C. difficile at a rate 15 (95% CI 7.2-32) times that of asymptomatic patients. Long-term care facility residents transmit at a rate of 27% (95% CI 13%-51%) that of hospitalized patients, and persons in the community at a rate of 0.1% (95% CI 0.062%-0.2%) that of hospitalized patients. Despite lower transmission rates for asymptomatic carriers and community sources, these transmission routes have a substantial effect on hospital-onset CDI because of the larger reservoir of hospitalized carriers and persons in the community. Asymptomatic carriers and community sources should be accounted for when designing and evaluating control interventions.
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