Evidence map›Paper›PMID 26982361›Full record

ArticleImmunity2016

Chitosan: An Adjuvant with an Unanticipated STING.

Nicolas Riteau, Alan Sher

Abstract readComment
PubMed Publisher
In one paragraph

Article in Immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

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  19. Modulation Effects ofVaccines · 2020
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Nicolas RiteauImmunobiology Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Alan SherImmunobiology Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: asher@niaid.nih.gov.

Funding

Innate Determinants of Microbial ImmunityZIAAI001044 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SHER, ALAN · 2009 to 2022
$8.8M
Vaccine Optimization ProgramZIAAI001186 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DUFFY, PATRICK · 2013 to 2020
$1.4M
Intramural NIH HHS
6 · The paper itself

Abstract

Adjuvants promote adaptive immunity through the triggering of innate signals that are largely poorly understood. In this issue of Immunity, Lavelle and colleagues describe an unexpected role for the DNA sensing cGAS-STING pathway in the mechanism of action of the Th1 cell-promoting polysaccharide adjuvant chitosan.

Indexed as

Adjuvants, ImmunologicAnimalsChitosanDendritic CellsFemaleHumansMembrane ProteinsMitochondriaNucleotidyltransferasesTh1 CellsAdjuvants, ImmunologicChitosanMembrane ProteinsNucleotidyltransferases

Identifiers

PMID26982361

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.