Evidence map›Paper›PMID 26982359›Full record

ArticleImmunity2016

Taking the Broad View on B Cell Affinity Maturation.

Karlynn E Neu, Patrick C Wilson

Abstract readComment
PubMed Publisher
In one paragraph

Article in Immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Karlynn E NeuCommittee on Immunology, The Knapp Center of Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA.
Patrick C WilsonCommittee on Immunology, The Knapp Center of Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA; The Department of Medicine, The University of Chicago, Chicago, IL 60637, USA. Electronic address: wilsonp@uchicago.edu.

Funding

Toward a Universal Influenza Virus VaccineP01AI097092 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2012 to 2022
$17.6M
Understanding Human B Cell Responses to Influenza to Improve the Influenza U19AI109946 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RAVETCH, JEFFREY VICTOR · 2014 to 2018
$9.6M
NIAID NIH HHS P01 AI097092NIAID NIH HHS U19 AI109946
6 · The paper itself

Abstract

Germinal center (GC) responses are required for the generation of high-affinity antigen-specific B cells. Kuraoka et al. (2016) explore the importance of inter-clonal competition in GC affinity maturation through the use of complex immunizing antigens and discover an unexpected increase in clonal diversity over the course of the response.

Indexed as

Clonal Selection, Antigen-MediatedAnimalsB-LymphocytesFemaleGerminal CenterHumansReceptors, Antigen, B-CellReceptors, Antigen, B-Cell

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.