ArticleTherapeutic hypothermia and temperature management2016
Intractable Central Hyperthermia in the Setting of Brainstem Hemorrhage.
Article in Therapeutic hypothermia and temperature management, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03496545 (Efficacy of Bromocriptine to Reduce Body Temperature in Febrile Critically-ill Adults With Acute Neurologic Disease), which is not on this map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Bromocriptine to Reduce Body Temperature in Febrile Critically-ill Adults With Acute Neurologic Disease: an Open-label, Blinded Endpoint, Randomized Controlled Trial
Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Effectiveness and Safety of Minimally Invasive Surgery for Infratentorial Hemorrhages: A Meta-Analysis of Clinical and Technical Outcomes.Asian journal of neurosurgery · 2026Review
- Central Fever-Associated Thrombocytopenia Following Pontine Hemorrhage: Resolution With Targeted Temperature Management.Journal of clinical neurology (Seoul, Korea) · 2025Article
- Clinical novel exploration of intractable fever in stroke rehabilitation: a single-center cross-sectional retrospective study.Scientific reports · 2025Article
- When a Dead Patient Is Not Really Dead: Lazarus Phenomenon.Case reports in critical care · 2020Article
- Central Hyperthermia Treated with Bromocriptine.Case reports in neurological medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperthermia from a central cause is associated with increased morbidity and mortality. Dysfunction of brainstem thermoregulatory pathways may explain the intractable rise in temperature. Antipyretics, dantrolene, bromocriptine, and surface and intravascular cooling devices have been attempted for temperature control. We report the case of a 54-year-old woman with history of hypertension who presented with pontine hemorrhage with extension into the midbrain and medulla. On days 8-9 of her hospital admission, she developed intractable fever and expired the same day despite aggressive treatment of hypothermia, including antipyretics, ice lavage, cold fluid boluses, surface cooling, dantrolene, and bromocriptine. Hyperthermia from brainstem hemorrhage can be difficult to manage with current treatment options. Early recognition of those patients who may develop hyperthermia could lead to early intervention and possibly better outcomes. More evidence from prospective randomized controlled trials will elucidate the risk-benefit profile of achieving normothermia with aggressive fever control in these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.